SCHEMBL8907248

SCHEMBL8907248

CCOC(=O)/C(C)=C\CCl.c1ccc(P(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.45
KMT2A Q03164 4/20 0.45
ALDH1A1 P00352 6/20 0.40
MAPT P10636 5/20 0.40
GAA P10253 2/20 0.40
TDP1 Q9NUW8 1/20 0.40
CYP1A2 P05177 1/20 0.39
CYP2C19 P33261 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.37
LMNA P02545 3/20 0.37
KDM4E B2RXH2 2/20 0.37
DHODH Q02127 1/20 0.37
PLIN1 O60240 1/20 0.37
POLB P06746 1/20 0.37
PLIN5 Q00G26 1/20 0.37
ABHD5 Q8WTS1 1/20 0.37
TSHR P16473 1/20 0.37
HSP90AA1 P07900 1/20 0.36
HPGD P15428 1/20 0.36
S1PR4 O95977 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10387880 0.81 GLO1 (0.47) MEN1KMT2AALDH1A1MAPTGAA
SCHEMBL8576396 0.81 GLO1 (0.47) MEN1KMT2AALDH1A1MAPTGAA
SCHEMBL8147465 0.81 GLO1 (0.47) MEN1KMT2AALDH1A1MAPTGAA
Ethyl Pyruvate SCHEMBL29019914 0.80 KMT2A (0.50) MEN1KMT2AALDH1A1MAPTGAA
Ethyl Acetate SCHEMBL811125 0.76 ALDH1A1 (0.54) MEN1KMT2AALDH1A1MAPTGAA
SCHEMBL28273314 0.76 ALDH1A1 (0.56) MEN1KMT2AALDH1A1MAPTTDP1
SCHEMBL6074460 0.75 SMN1; SMN2 (0.46) MEN1KMT2AALDH1A1GAATDP1
Ethyl Acetate SCHEMBL9419114 0.75 ALDH1A1 (0.52) MEN1KMT2AALDH1A1MAPTGAA
Ethyl Acetate SCHEMBL9063181 0.75 ALDH1A1 (0.52) MEN1KMT2AALDH1A1MAPTGAA
SCHEMBL28359555 0.74 TSHR (0.48) MEN1KMT2AALDH1A1MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5681977-A Method for the production of (3-alkoxycarbonyl-2-butenyl) triphenylphosphonium salts ROCHE VITAMINS INC. (US) 1997-10-28 US disclosed
US-5502236-A Method for the production of (3-alkoxycarbonyl-2-butenyl)triphenylphosphonium salts HOFFMANN-LA ROCHE INC. (US) 1996-03-26 US disclosed