Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 2/20 | 0.47 |
| ▸ | MMP12 | P39900 | 2/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3836194 | 0.89 | MMP8 (0.58) | MEN1KMT2APOLBALDH1A1CA2 | |
| SCHEMBL6795676 | 0.81 | MEN1 (0.54) | MEN1KMT2APOLBALDH1A1CA2 | |
| SCHEMBL6491355 | 0.81 | CA2 (0.55) | MEN1KMT2APOLBALDH1A1CA2 | |
| SCHEMBL6626226 | 0.79 | MEN1 (0.61) | MEN1KMT2APOLBALDH1A1L3MBTL1 | |
| SCHEMBL634963 | 0.79 | CA1 (0.61) | MEN1KMT2AALDH1A1CA2MMP8 | |
| SCHEMBL27737212 | 0.78 | MEN1 (0.51) | MEN1KMT2APOLBCA2MMP8 | |
| SCHEMBL10895642 | 0.78 | CA2 (0.56) | MEN1KMT2APOLBALDH1A1CA2 | |
| SCHEMBL19798386 | 0.77 | MEN1 (0.50) | MEN1KMT2APOLBALDH1A1CA2 | |
| SCHEMBL12890231 | 0.77 | KMT2A (0.50) | MEN1KMT2APOLBALDH1A1CA2 | |
| SCHEMBL28028806 | 0.76 | MEN1 (0.90) | MEN1KMT2APOLBALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5587393-A | ANGIOTENSIN ANTAGONIST USEFUL IN TREATING HYPERTENSION | DR. KARL THOMAE GMBH (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5385925-A | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1995-01-31 | — | — | US | disclosed |