Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.45 |
| ▸ | PPARA | Q07869 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8907692 | 0.87 | ERN1 (0.48) | PPARGPPARAATML3MBTL1KMT2A | |
| SCHEMBL12419937 | 0.80 | PPARG (0.50) | PPARGPPARAATML3MBTL1KMT2A | |
| SCHEMBL30232935 | 0.78 | CA1 (0.61) | PPARGPPARAATML3MBTL1KMT2A | |
| SCHEMBL15337170 | 0.78 | PPARG (0.51) | PPARGPPARAATML3MBTL1KMT2A | |
| SCHEMBL542559 | 0.78 | CA1 (0.61) | PPARGPPARAATML3MBTL1KMT2A | |
| SCHEMBL8906623 | 0.77 | PPARG (0.48) | PPARGPPARAATML3MBTL1KMT2A | |
| SCHEMBL3543244 | 0.77 | MAPT (0.55) | PPARGPPARAATML3MBTL1KMT2A | |
| SCHEMBL3273922 | 0.77 | CCR6 (0.49) | PPARGPPARAATML3MBTL1KMT2A | |
| SCHEMBL20860850 | 0.77 | ASIC3 (0.47) | L3MBTL1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL15563640 | 0.76 | CA1 (0.62) | ATML3MBTL1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686478-A | Endothelin antagonists | MERCK & CO. INC. (US) | 1997-11-11 | — | — | US | disclosed |
| EP-0710235-A4 | — | — | 1996-06-12 | — | — | EP | disclosed |
| EP-0710235-A1 | ENDOTHELIN ANTAGONISTS | MERCK & CO. INC. (US) | 1996-05-08 | — | — | EP | disclosed |
| WO-1995003295-A1 | ENDOTHELIN ANTAGONISTS | MERCK & CO., INC. (US) | 1995-02-02 | — | — | WO | disclosed |