Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908199 | 0.87 | DRD2 (0.42) | DRD2DRD3DRD4 | |
| SCHEMBL8906800 | 0.86 | DRD2 (0.46) | DRD2DRD3DRD4 | |
| SCHEMBL8907408 | 0.86 | — | — | |
| SCHEMBL8906856 | 0.81 | DRD2 (0.46) | DRD2DRD3DRD4 | |
| SCHEMBL8908180 | 0.81 | GRIN1 (0.36) | — | |
| SCHEMBL8906582 | 0.80 | PIK3CA (0.34) | DRD2DRD3DRD4 | |
| SCHEMBL8906794 | 0.77 | — | — | |
| SCHEMBL8908126 | 0.75 | DRD2 (0.42) | DRD2DRD3DRD4 | |
| SCHEMBL8906708 | 0.74 | DRD2 (0.32) | DRD2DRD3DRD4 | |
| SCHEMBL9467917 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556332-B1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER LAMBERT CO (US) | 1996-03-20 | — | — | EP | claimed |
| US-5273977-A | 1-Phenylethylidynealkylene-4-phenyl-1,2,5,6-tetrahydropyridines | WARNER-LAMBERT COMPANY (US) | 1993-12-28 | — | — | US | claimed |
| WO-1992007831-A1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-14 | — | — | WO | claimed |
| US-5620988-A | Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1997-04-15 | — | — | US | disclosed |
| EP-0556332-B1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER LAMBERT CO (US) | 1996-03-20 | — | — | EP | disclosed |
| US-5466698-A | Substituted tetrahydrophyridines and hydroxypiperidines as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1995-11-14 | — | — | US | disclosed |
| US-5273977-A | 1-Phenylethylidynealkylene-4-phenyl-1,2,5,6-tetrahydropyridines | WARNER-LAMBERT COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| WO-1992007831-A1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-14 | — | — | WO | disclosed |