SCHEMBL8907770

SCHEMBL8907770

CN(C)c1ccc(-c2c(-c3ccccc3)n(Cc3cccc(C#N)c3)c(=O)n2Cc2cccc(C#N)c2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFTR P13569 1/20 0.49
ALDH1A1 P00352 3/20 0.45
ROCK2 O75116 2/20 0.43
CNR1 P21554 1/20 0.42
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
CREBBP Q92793 1/20 0.41
GRIN1 Q05586 2/20 0.41
GRIN2B Q13224 2/20 0.41
DRD4 P21917 1/20 0.41
CCR2 P41597 1/20 0.40
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
FEN1 P39748 1/20 0.39
MAPT P10636 1/20 0.39
LMNA P02545 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8439957 0.89 CFTR (0.58) CFTRALDH1A1ROCK2CNR1HDAC8
SCHEMBL8908061 0.84 CFTR (0.57) CFTRALDH1A1ROCK2CNR1HDAC8
SCHEMBL8487543 0.84 CFTR (0.54) CFTRALDH1A1ROCK2CNR1HDAC8
SCHEMBL8440689 0.83 HDAC8 (0.49) CFTRALDH1A1HDAC8HDAC6CREBBP
SCHEMBL8440897 0.81 CFTR (0.51) CFTRALDH1A1ROCK2CNR1HDAC8
SCHEMBL8908297 0.81 CFTR (0.53) CFTRALDH1A1ROCK2CNR1HDAC8
SCHEMBL8443456 0.78 HDAC8 (0.52) CFTRALDH1A1HDAC8HDAC6GRIN1
SCHEMBL8909337 0.78 F10 (0.51)
SCHEMBL8443423 0.77 CFTR (0.52) CFTRALDH1A1ROCK2HDAC8HDAC6
SCHEMBL7359317 0.76 KLKB1 (0.51) ALDH1A1ROCK2CREBBPGRIN1GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5612363-A FACTOR XA INHIBITORS BERLEX LABORATORIES, INC. (US) 1997-03-18 US disclosed