SCHEMBL8440689

SCHEMBL8440689

CN(C)C(=O)c1cccc(Cn2c(-c3ccccc3)c(-c3ccccc3)n(Cc3cccc(C#N)c3)c2=O)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 3/20 0.49
HDAC6 Q9UBN7 3/20 0.49
CFTR P13569 1/20 0.46
ALDH1A1 P00352 1/20 0.44
RHEB Q15382 1/20 0.42
CCR2 P41597 1/20 0.42
HDAC1 Q13547 1/20 0.42
FAAH O00519 2/20 0.41
MGLL Q99685 1/20 0.41
FEN1 P39748 1/20 0.41
PDK1 Q15118 1/20 0.41
KLK1 P06870 2/20 0.41
KLKB1 P03952 1/20 0.41
POLB P06746 1/20 0.40
MEN1 O00255 1/20 0.40
USP2 O75604 1/20 0.40
KMT2A Q03164 1/20 0.40
FYN P06241 1/20 0.39
VNN1 O95497 1/20 0.39
DRD4 P21917 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7354793 0.87 HDAC8 (0.45) HDAC8HDAC6CFTRRHEBHDAC1
SCHEMBL8443456 0.85 HDAC8 (0.52) HDAC8HDAC6CFTRALDH1A1HDAC1
SCHEMBL8439957 0.85 CFTR (0.58) HDAC8HDAC6CFTRALDH1A1CCR2
SCHEMBL8907770 0.83 CFTR (0.49) HDAC8HDAC6CFTRALDH1A1CCR2
SCHEMBL8689074 0.81 LMNA (0.39) HDAC8HDAC6ALDH1A1RHEBFAAH
SCHEMBL8908061 0.81 CFTR (0.57) HDAC8HDAC6CFTRALDH1A1CCR2
SCHEMBL8487543 0.81 CFTR (0.54) HDAC8HDAC6CFTRALDH1A1CCR2
SCHEMBL8440897 0.80 CFTR (0.51) HDAC8HDAC6CFTRALDH1A1CCR2
SCHEMBL8908297 0.77 CFTR (0.53) HDAC8HDAC6CFTRALDH1A1CCR2
SCHEMBL8693003 0.77 RHEB (0.39) HDAC8HDAC6RHEBFAAHMGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5863914-A ADMINISTERING TO HUMAN N,N-DIMETHYLBENZENE OR N,N-DIMETHYLNAPHTHALENE-CYCLIC UREA DERIVATIVE TO TREAT A DISEASE-STATE CAUSED BY INHIBITION OF FACTOR XA MOHAN RAJU (US) 1999-01-26 US disclosed
US-5859005-A INHIBITORS OF THROMBIN AND FACTOR XA BERLEX LABORATORIES, INC. (US) 1999-01-12 US disclosed
US-5731308-A N,N-di(aryl) cyclic urea derivatives as anti-coagulants BERLEX LABORATORIES, INC. (US) 1998-03-24 US disclosed
US-5731311-A N,N-di(aryl) cyclic urea derivatives as anti-coagulants BERLEX LABORATORIES, INC. (US) 1998-03-24 US disclosed
US-5728697-A INHIBITORS OF FACTOR X BERLEX LABORATORIES, INC. (US) 1998-03-17 US disclosed
US-5726173-A ANTICOAGULANTS BERLEX LABORATORIES, INC. (US) 1998-03-10 US disclosed
US-5726198-A FOR INHIBITING COAGULATION ENZYMES BERLEX LABORATORIES, INC. (US) 1998-03-10 US disclosed
US-5612363-A FACTOR XA INHIBITORS BERLEX LABORATORIES, INC. (US) 1997-03-18 US disclosed