Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | HTT | P42858 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | SMO | Q99835 | 2/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14102455 | 0.88 | CSNK1D (0.57) | MAPTHTTLMNANPSR1ALDH1A1 | |
| SCHEMBL14102661 | 0.78 | SMO (0.40) | MAPTHTTLMNANPSR1ALDH1A1 | |
| SCHEMBL13977440 | 0.77 | NPSR1 (1.00) | MAPTHTTLMNANPSR1ALDH1A1 | |
| SCHEMBL1753096 | 0.75 | CSNK1D (0.54) | MAPTHTTLMNANPSR1ALDH1A1 | |
| SCHEMBL14679251 | 0.75 | LMNA (0.56) | MAPTHTTLMNANPSR1ALDH1A1 | |
| SCHEMBL12706599 | 0.74 | CSNK1D (0.54) | MAPTHTTLMNANPSR1ALDH1A1 | |
| SCHEMBL1752999 | 0.72 | MAPT (0.59) | MAPTHTTLMNANPSR1ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL17728179 | 0.70 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2MAPK1HSD17B10CSNK1D | |
| SCHEMBL1753107 | 0.69 | LMNA (0.59) | MAPTHTTLMNANPSR1ALDH1A1 | |
| SCHEMBL13490966 | 0.69 | SMO (0.83) | HTTALDH1A1SMN1; SMN2HSD17B10SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188096-B2 | Protein kinase targeted therapeutics | NORTHWESTERN UNIVERSITY (US) | 2012-05-29 | — | — | US | disclosed |
| US-20110166153-A1 | Protein Kinase Targeted Therapeutics | NORTHWESTERN UNIVERSITY (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166153-A1 | Protein Kinase Targeted Therapeutics | MAP3K1, MAP3K6, MAPK1 | MAPT 371/4885HTT 2159/4885LMNA 1694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.