Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 5/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 5/20 | 0.33 |
| ▸ | SI | P14410 | 5/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.33 |
| ▸ | PARP1 | P09874 | 3/20 | 0.33 |
| ▸ | F12 | P00748 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL724308 | 0.87 | MAPK1 (0.51) | MAPK1POLBATMMAPTLMNA | |
| SCHEMBL30144927 | 0.86 | PARP1 (0.47) | MAPK1POLBATMPARP1DHODH | |
| SCHEMBL2947453 | 0.82 | PKN1 (0.46) | MAPK1POLBATMMAPTLMNA | |
| SCHEMBL378660 | 0.75 | POLB (0.50) | MAPK1POLBATMMAPTLMNA | |
| SCHEMBL7046048 | 0.74 | MAPK1 (0.46) | MAPK1POLBATMMAPTLMNA | |
| SCHEMBL1011867 | 0.74 | MAPK1 (0.42) | MAPK1POLBATMMAPTLMNA | |
| SCHEMBL3282850 | 0.73 | GRM2 (0.50) | MAPK1POLBATMMAPTLMNA | |
| SCHEMBL2113290 | 0.73 | MAPK1 (0.48) | MAPK1POLBATMMAPTLMNA | |
| Water SCHEMBL3673310 | 0.73 | POLB (0.48) | MAPK1POLBATMMAPTLMNA | |
| SCHEMBL2670682 | 0.73 | POLB (0.48) | MAPK1POLBATMMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5672605-A | ADMINISTERING TO TREAT AUTOIMMUNE DISORDERS, TRANSPLANT REJECTION | ABBOTT LABORATORIES (US) | 1997-09-30 | — | — | US | disclosed |
| US-5583139-A | Marcolide immunomodulators | ABBOTT LABORATORIES (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0729471-A1 | SEMISYNTHETIC ANALOGS OF RAPAMYCIN (MACROLIDES) BEING IMMUNOMODULATORS | Abbott Laboratories (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5527907-A | IMMUNOSUPPRESSANTS | ABBOTT LABORATORIES (US) | 1996-06-18 | — | — | US | disclosed |
| WO-1995014023-A1 | SEMISYNTHETIC ANALOGS OF RAPAMYCIN (MACROLIDES) BEING IMMUNOMODULATORS | ABBOTT LABORATORIES (US) | 1995-05-26 | — | — | WO | disclosed |