SCHEMBL724308

SCHEMBL724308

O=C(O)c1cccc2c1nnn2O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.51
MAPT P10636 2/20 0.51
POLB P06746 1/20 0.44
ATM Q13315 1/20 0.44
ALDH1A1 P00352 3/20 0.43
KDM4E B2RXH2 2/20 0.43
HPGD P15428 1/20 0.43
DHODH Q02127 6/20 0.42
PARP1 P09874 1/20 0.41
ALOX15 P16050 1/20 0.40
HSD17B10 Q99714 1/20 0.39
FABP3 P05413 1/20 0.38
FABP4 P15090 1/20 0.38
FABP5 Q01469 1/20 0.38
LMNA P02545 1/20 0.37
KDM4A O75164 1/20 0.37
RAB9A P51151 1/20 0.37
EGLN1 Q9GZT9 1/20 0.37
HIF1AN Q9NWT6 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8908200 0.87 MAPK1 (0.46) MAPK1MAPTPOLBATMKDM4E
SCHEMBL30144927 0.84 PARP1 (0.47) MAPK1POLBATMDHODHPARP1
SCHEMBL10347831 0.81 ALDH1A1 (0.42) MAPK1MAPTALDH1A1KDM4EHPGD
SCHEMBL30622603 0.81 HCAR3 (0.45) MAPK1MAPTALDH1A1KDM4EHPGD
SCHEMBL11022153 0.81 ALDH1A1 (0.42) MAPK1MAPTALDH1A1KDM4EHPGD
SCHEMBL2012449 0.81 HCAR3 (0.45) MAPK1MAPTALDH1A1KDM4EHPGD
SCHEMBL2947453 0.80 PKN1 (0.46) MAPK1MAPTPOLBATMALDH1A1
SCHEMBL16610475 0.77 GRM2 (0.40) ALDH1A1KDM4EHPGDRAB9A
SCHEMBL1154415 0.76 MAPK1 (0.48) MAPK1MAPTPOLBATMKDM4E
SCHEMBL1011868 0.75 MAPK1 (0.41) MAPK1MAPTPOLBATMKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111155141-B Method for electrochemically synthesizing gem-difluoroolefin 中国科学技术大学 2022-01-11 CN claimed
CN-111155141-A Method for electrochemically synthesizing gem-difluoroolefin 中国科学技术大学 2020-05-15 CN claimed
US-9475916-B2 Process for curing surface-coating compositions ALLNEX AUSTRIA GMBH (AT) 2016-10-25 US claimed
US-20140356540-A1 PROCESS FOR CURING SURFACE-COATING COMPOSITIONS CYTEC AUSTRIA GMBH (AT) 2014-12-04 US claimed
EP-2655527-A1 PROCESS FOR CURING SURFACE-COATING COMPOSITIONS ALLNEX AUSTRIA GmbH (AT) 2013-10-30 EP claimed
WO-2012085016-A1 PROCESS FOR CURING SURFACE-COATING COMPOSITIONS CYTEC AUSTRIA GMBH (AT) 2012-06-28 WO claimed
US-20060217281-A1 Oxidation system containing a macrocyclic metal complex, the production thereof and its use LANXESS B.V. (NL) 2006-09-28 US claimed
EP-1606447-A1 OXIDATION SYSTEM CONTAINING A MACROCYCLIC METAL COMPLEX, THE PRODUCTION THEREOF AND ITS USE Lanxess B.V. (NL) 2005-12-21 EP claimed
EP-1092762-B1 Storage stable compositions comprising mediators, peroxide compounds and pH stabilizers, and their use in enzymatic bleaching systems BAYER CHEMICALS AG (DE) 2004-12-08 EP claimed
WO-2004083516-A1 OXIDATION SYSTEM CONTAINING A MACROCYCLIC METAL COMPLEX, THE PRODUCTION THEREOF AND ITS USE LANXESS B.V. (NL) 2004-09-30 WO claimed
US-6380142-B1 FOR USE IN ENZYMATIC TWO-COMPONENT BLEACHING SYSTEMS BAYER AKTIENGESELLSCHAFT (DE) 2002-04-30 US claimed
EP-1092762-A1 Storage stable compositions comprising mediators, peroxide compounds and pH stabilizers, and their use in enzymatic bleaching systems Bayer Aktiengesellschaft (DE) 2001-04-18 EP claimed
CN-111155141-B Method for electrochemically synthesizing gem-difluoroolefin 中国科学技术大学 2022-01-11 CN disclosed
CN-111155141-A Method for electrochemically synthesizing gem-difluoroolefin 中国科学技术大学 2020-05-15 CN disclosed
CN-105384608-B A kind of cumene amphyl and preparation method thereof 四川海思科制药有限公司 2019-08-16 CN disclosed
EP-2609426-B1 FLUORESCENCE LABELING REAGENTS AND USES THEREOF TEXAS A & M UNIV SYS (US) 2018-12-19 EP disclosed
CN-1440401-A Amino substituted dibenzothiophene derivatives for treatmnt of disorders mediated by NP Y5 receptor ASTRAZENECA AB (SE) 2003-09-03 CN disclosed
CN-1384823-A Process for preparing oxo-oxazoline or alloamino acid derivatives SHIONOGI & CO (JP) 2002-12-11 CN disclosed
US-6380142-B1 FOR USE IN ENZYMATIC TWO-COMPONENT BLEACHING SYSTEMS BAYER AKTIENGESELLSCHAFT (DE) 2002-04-30 US disclosed
EP-1092762-A1 Storage stable compositions comprising mediators, peroxide compounds and pH stabilizers, and their use in enzymatic bleaching systems Bayer Aktiengesellschaft (DE) 2001-04-18 EP disclosed