SCHEMBL8908702

SCHEMBL8908702

CN(C)c1ccc(Nc2nc(Nc3ccccc3)c3ccccc3n2)cc1

nearest known ligand 0.74

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
NPY5R Q15761 7/20 0.74
KDM1A O60341 10/20 0.69
NPC1 O15118 1/20 0.69
PKM P14618 1/20 0.69
RAB9A P51151 1/20 0.69
KLF5 Q13887 1/20 0.69
L3MBTL1 Q9Y468 1/20 0.69
IGF1R P08069 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8900394 0.99 NPY5R (0.72) NPY5RKDM1ANPC1PKMRAB9A
SCHEMBL8890079 0.90 NPY5R (0.81) NPY5RKDM1ANPC1PKMRAB9A
Hydrochloric Acid SCHEMBL8890008 0.89 NPY5R (0.79) NPY5RKDM1ANPC1PKMRAB9A
SCHEMBL8901496 0.88 NPY5R (0.68) NPY5RKDM1ANPC1PKMRAB9A
Hydrochloric Acid SCHEMBL8913197 0.87 NPY5R (0.67) NPY5RKDM1ANPC1PKMRAB9A
SCHEMBL2591063 0.86 NPY5R (1.00) NPY5RNPC1PKMRAB9A
SCHEMBL8893267 0.86 NPY5R (0.60) NPY5RKDM1ANPC1PKMRAB9A
SCHEMBL8901456 0.85 NPY5R (1.00) NPY5RKDM1A
Hydrochloric Acid SCHEMBL6039677 0.85 NPY5R (0.96) NPY5RNPC1PKMRAB9A
Hydrochloric Acid SCHEMBL8909035 0.84 NPY5R (0.59) NPY5RKDM1ANPC1PKMRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997020822-A1 QUINAZOLIN-2,4-DIAZIRINES AS NPY RECEPTOR ANTAGONIST NOVARTIS AG (CH) 1997-06-12 WO claimed