Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.75 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.64 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5419894 | 0.89 | CYP3A4 (0.62) | CYP3A4CYP26A1CYP26B1NPC1TP53 | |
| SCHEMBL14371956 | 0.89 | CYP3A4 (0.67) | CYP3A4CYP26A1CYP26B1NPC1TP53 | |
| SCHEMBL5184246 | 0.89 | CYP26A1 (0.74) | CYP3A4CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL5431263 | 0.88 | CYP3A4 (0.61) | CYP3A4CYP26A1CYP26B1NPC1TP53 | |
| SCHEMBL8839159 | 0.88 | CYP26A1 (0.65) | CYP3A4CYP26A1CYP26B1NPC1TP53 | |
| SCHEMBL8839117 | 0.88 | CYP26A1 (0.65) | CYP3A4CYP26A1CYP26B1NPC1TP53 | |
| SCHEMBL8839086 | 0.88 | CYP3A4 (0.77) | CYP3A4CYP26A1CYP26B1NPC1TP53 | |
| SCHEMBL8908697 | 0.87 | CYP26A1 (0.77) | CYP3A4CYP26A1CYP26B1NPC1TP53 | |
| SCHEMBL8908692 | 0.87 | CYP26A1 (0.77) | CYP3A4CYP26A1CYP26B1NPC1TP53 | |
| SCHEMBL9256097 | 0.87 | CYP3A4 (0.57) | CYP3A4CYP26A1CYP26B1NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654331-A | SKIN AND RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1997-08-05 | — | — | US | disclosed |
| US-5476860-A | Diaromatic compounds derived from a salicylic unit and their use in human and veterinary medicine and in cosmetics | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD GALDERMA) (FR) | 1995-12-19 | — | — | US | disclosed |