Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | USP8 | P40818 | 2/20 | 0.46 |
| ▸ | USP7 | Q93009 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 7/20 | 0.42 |
| ▸ | PTPRC | P08575 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | USP1 | O94782 | 1/20 | 0.39 |
| ▸ | OTUB1 | Q96FW1 | 1/20 | 0.39 |
| ▸ | USP36 | Q9P275 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908559 | 0.96 | ALDH1A1 (0.53) | ALDH1A1POLBRXFP1USP8USP7 | |
| SCHEMBL6237073 | 0.89 | POLB (0.58) | ALDH1A1POLBRXFP1IDO1PTPRC | |
| SCHEMBL9815972 | 0.85 | PTPRC (0.42) | ALDH1A1POLBRXFP1USP8USP7 | |
| SCHEMBL8908230 | 0.76 | KMT2A (0.41) | ALDH1A1POLBRXFP1USP8USP7 | |
| SCHEMBL8908233 | 0.76 | KMT2A (0.41) | ALDH1A1POLBRXFP1USP8USP7 | |
| SCHEMBL1888851 | 0.69 | KDM4E (0.52) | ALDH1A1POLBRAB9AKMT2ANPC1 | |
| SCHEMBL30204979 | 0.67 | ALDH1A1 (1.00) | ALDH1A1POLBRXFP1IDO1PTPRC | |
| SCHEMBL414535 | 0.67 | ALDH1A1 (1.00) | ALDH1A1POLBRXFP1IDO1PTPRC | |
| Anthraquinone SCHEMBL28787967 | 0.67 | ALDH1A1 (0.50) | ALDH1A1POLBIDO1RAB9AKMT2A | |
| Anthraquinone SCHEMBL28141482 | 0.65 | MEN1 (0.86) | ALDH1A1POLBIDO1PTPRCRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682657-B1 | 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1997-11-19 | — | — | EP | claimed |
| EP-0682657-A1 | 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1995-11-22 | — | — | EP | claimed |
| US-5468748-A | Nervous system and psychological disorders; antagonize glycine binding site on N-methylaspartic acid receptor complex | NOVO NORDISK A/S (DK) | 1995-11-21 | — | — | US | claimed |
| WO-1994018175-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-08-18 | — | — | WO | claimed |
| EP-0682657-B1 | 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1997-11-19 | — | — | EP | disclosed |
| US-5646146-A | CENTRAL NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1997-07-08 | — | — | US | disclosed |
| EP-0682657-A1 | 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1995-11-22 | — | — | EP | disclosed |
| US-5468748-A | Nervous system and psychological disorders; antagonize glycine binding site on N-methylaspartic acid receptor complex | NOVO NORDISK A/S (DK) | 1995-11-21 | — | — | US | disclosed |
| WO-1994018175-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-08-18 | — | — | WO | disclosed |