Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | BHMT | Q93088 | 1/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2045388 | 1.00 | TDP1 (0.48) | TDP1SMN1; SMN2SLC22A6FOLH1MAPT | |
| SCHEMBL28422790 | 0.97 | TDP1 (0.46) | TDP1SMN1; SMN2SLC22A6FOLH1MAPT | |
| SCHEMBL517199 | 0.91 | SLC22A6 (0.45) | TDP1SMN1; SMN2SLC22A6MAPTALOX15 | |
| SCHEMBL9517361 | 0.86 | TDP1 (0.37) | TDP1SMN1; SMN2SLC22A6FOLH1BHMT | |
| Succinic Acid SCHEMBL30420896 | 0.83 | LMNA (0.50) | TDP1SMN1; SMN2SLC22A6FOLH1LMNA | |
| SCHEMBL11309347 | 0.82 | TDP1 (0.48) | TDP1SMN1; SMN2LMNAFFAR3ALDH1A1 | |
| SCHEMBL4623050 | 0.82 | TDP1 (0.35) | TDP1SMN1; SMN2FOLH1MAPTALOX15 | |
| Ethylenediamine SCHEMBL29025807 | 0.81 | GABRR1 (0.42) | TDP1SMN1; SMN2SLC22A6ALOX15BHMT | |
| SCHEMBL1702651 | 0.81 | SLC22A6 (0.38) | TDP1SMN1; SMN2SLC22A6MAPTALOX15 | |
| SCHEMBL9789924 | 0.81 | SLC22A6 (0.38) | TDP1SMN1; SMN2SLC22A6MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688946-A | DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | HOFFMANN LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |