Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 1.00 |
| ▸ | DRD3 | P35462 | 10/20 | 1.00 |
| ▸ | HTR1D | P28221 | 6/20 | 1.00 |
| ▸ | DRD4 | P21917 | 2/20 | 0.60 |
| ▸ | HTR5A | P47898 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9391465 | 1.00 | DRD2 (1.00) | DRD2DRD3HTR1DDRD4HTR5A | |
| SCHEMBL9406454 | 0.81 | MTNR1A (0.69) | DRD2DRD3HTR1D | |
| SCHEMBL2025137 | 0.81 | DRD2 (0.82) | DRD2DRD3HTR1DDRD4 | |
| SCHEMBL2025960 | 0.81 | DRD2 (0.82) | DRD2DRD3HTR1DDRD4 | |
| SCHEMBL2025138 | 0.81 | DRD2 (0.82) | DRD2DRD3HTR1DDRD4 | |
| Hydrochloric Acid SCHEMBL2024400 | 0.80 | DRD2 (0.81) | DRD2DRD3HTR1DDRD4 | |
| SCHEMBL8902966 | 0.78 | DRD2 (1.00) | DRD2DRD3HTR1D | |
| SCHEMBL8902681 | 0.78 | DRD2 (1.00) | DRD2DRD3HTR1D | |
| SCHEMBL8902678 | 0.78 | DRD2 (1.00) | DRD2DRD3HTR1D | |
| Hydrochloric Acid SCHEMBL8904336 | 0.77 | DRD2 (0.98) | DRD2DRD3HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5635537-A | ENANTIOMERS AND SALTS; HALOGEN SUBSTITUTION AT POSITION 5, AT POSITION 8 C1-C6 ALKYLCARBONYL OR OPTIONALLY SUBSTITUTED THIENYL OR FURANYL; FOR TREATMENT OF 5-HT NEUROTRANSMISSION DISORDERS; DEPRESSION; ANXIETY | ASTRA AKTIEBOLAG (SE) | 1997-06-03 | — | — | US | disclosed |
| EP-0399982-B1 | Novel 8-substituted-2-amino-tetralines | ASTRA AB (SE) | 1995-11-02 | — | — | EP | disclosed |
| EP-0399982-A1 | Novel 8-substituted-2-amino-tetralines | Astra Aktiebolag (SE) | 1990-11-28 | — | — | EP | disclosed |