SCHEMBL8909404

SCHEMBL8909404

O=C(NC(Cc1c[nH]cn1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)C1CC1)C(Cc1ccccc1)Cc1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
REN P00797 19/20 0.62
P2RX1 P51575 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9800511 0.93 REN (0.55) RENP2RX1
SCHEMBL8909157 0.93 REN (0.55) RENP2RX1
SCHEMBL9800473 0.92 REN (0.62) REN
SCHEMBL9227669 0.92 REN (0.60) REN
SCHEMBL7283229 0.92 REN (0.60) REN
SCHEMBL9800781 0.91 REN (0.55) RENP2RX1
SCHEMBL7305156 0.91 REN (0.65) REN
SCHEMBL9800778 0.90 REN (0.55) RENP2RX1
Remikiren SCHEMBL9556708 0.90 REN (0.76) REN
Remikiren SCHEMBL9556439 0.90 REN (0.76) REN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5688946-A DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS HOFFMANN LA ROCHE INC. (US) 1997-11-18 US claimed
US-5688946-A DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS HOFFMANN LA ROCHE INC. (US) 1997-11-18 US disclosed