Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.67 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 9/20 | 0.55 |
| ▸ | HTR1A | P08908 | 6/20 | 0.55 |
| ▸ | AGXT | P21549 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552675 | 0.80 | CYP19A1 (1.00) | CYP19A1 | |
| SCHEMBL23890351 | 0.76 | POLB (0.54) | CYP19A1LOXL2HTR2BHTR1AAGXT | |
| SCHEMBL14075637 | 0.76 | LOXL2 (0.69) | CYP19A1LOXL2HTR2BHTR1AAGXT | |
| SCHEMBL2979920 | 0.75 | HTR2B (0.74) | HTR2BHTR1ADRD2MEN1KMT2A | |
| SCHEMBL2987620 | 0.74 | HTR2B (0.72) | HTR2BHTR1ADRD2MEN1KMT2A | |
| SCHEMBL2983918 | 0.73 | HTR2B (0.70) | HTR2BHTR1ADRD2MEN1KMT2A | |
| SCHEMBL1418873 | 0.73 | MAPT (0.51) | CYP19A1LOXL2HTR2BHTR1AAGXT | |
| SCHEMBL29841388 | 0.73 | MAPT (0.51) | CYP19A1LOXL2HTR2BHTR1AAGXT | |
| SCHEMBL291730 | 0.72 | LOXL2 (0.64) | CYP19A1LOXL2HTR2BHTR1AAGXT | |
| SCHEMBL2090461 | 0.72 | LOXL2 (0.64) | CYP19A1LOXL2HTR2BHTR1AAGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111989311-B | Compound for inhibiting PGE2/EP4 signal transduction, preparation method thereof and application thereof in medicines | 凯复(苏州)生物医药有限公司 | 2022-03-22 | — | — | CN | disclosed |
| CN-111989311-A | Compound for inhibiting PGE2/EP4 signal transduction, preparation method thereof and application thereof in medicines | 凯复(苏州)生物医药有限公司 | 2020-11-24 | — | — | CN | disclosed |
| US-5679694-A | LOW TOXICITY AGAINST NORMAL CELL LINES | THE WELLCOME FOUNDATION LTD. (GB) | 1997-10-21 | — | — | US | disclosed |
| EP-0651750-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-05-10 | — | — | EP | disclosed |
| WO-1994002483-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |