Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 4/20 | 0.56 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.56 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.41 |
| ▸ | XIAP | P98170 | 7/20 | 0.39 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8909721 | 1.00 | GHSR (0.56) | GHSRAGTR1RIPK1XIAPCHIA | |
| SCHEMBL8909822 | 0.92 | GHSR (0.60) | GHSRAGTR1RIPK1XIAPCHIA | |
| SCHEMBL8909818 | 0.92 | GHSR (0.60) | GHSRAGTR1RIPK1XIAPCHIA | |
| SCHEMBL9025540 | 0.89 | GHSR (0.68) | GHSRAGTR1XIAP | |
| SCHEMBL9025533 | 0.89 | GHSR (0.68) | GHSRAGTR1XIAP | |
| SCHEMBL8910280 | 0.88 | GHSR (0.44) | GHSRAGTR1RIPK1XIAP | |
| SCHEMBL8910284 | 0.88 | GHSR (0.44) | GHSRAGTR1RIPK1XIAP | |
| SCHEMBL8909382 | 0.88 | GHSR (0.44) | GHSRAGTR1RIPK1XIAPCHIA | |
| SCHEMBL8909302 | 0.84 | GHSR (0.68) | GHSRAGTR1RIPK1XIAP | |
| SCHEMBL8909668 | 0.84 | GHSR (0.56) | GHSRAGTR1RIPK1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5606054-A | Heterocyclic-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1997-02-25 | — | — | US | claimed |
| WO-1995016692-A1 | HETEROCYCLIC-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-06-22 | — | — | WO | claimed |
| US-5606054-A | Heterocyclic-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1997-02-25 | — | — | US | disclosed |
| WO-1995016692-A1 | HETEROCYCLIC-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-06-22 | — | — | WO | disclosed |