Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | SCN4A | P35499 | 6/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442204 | 0.83 | LMNA (0.63) | LMNAMAOAPTGS1SCN4ACYP2D6 | |
| SCHEMBL366154 | 0.83 | LMNA (0.63) | LMNAMAOAPTGS1SCN4ACYP2D6 | |
| SCHEMBL507119 | 0.83 | LMNA (0.63) | LMNAMAOAPTGS1SCN4ACYP2D6 | |
| SCHEMBL19618883 | 0.82 | CYP3A4 (0.55) | LMNAMAOAPTGS1SCN4ACYP2D6 | |
| SCHEMBL19618917 | 0.82 | CYP3A4 (0.55) | LMNAMAOAPTGS1SCN4ACYP2D6 | |
| Hydrochloric Acid SCHEMBL28934580 | 0.81 | LMNA (0.61) | LMNAMAOAPTGS1SCN4ACYP2D6 | |
| Hydrochloric Acid SCHEMBL21315607 | 0.81 | LMNA (0.61) | LMNAMAOAPTGS1SCN4ACYP2D6 | |
| Ammonia Solution, Strong SCHEMBL9819193 | 0.81 | LMNA (0.61) | LMNAMAOAPTGS1SCN4ACYP2D6 | |
| Hydrochloric Acid SCHEMBL19668691 | 0.81 | LMNA (0.61) | LMNAMAOAPTGS1SCN4ACYP2D6 | |
| SCHEMBL18295391 | 0.79 | SCN4A (0.47) | LMNASCN4ACYP2D6CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5672588-A | Purine derivatives | NOVO NORDISK A/S (DK) | 1997-09-30 | — | — | US | disclosed |
| EP-0603348-A1 | PURINE DERIVATIVES | NOVO NORDISK A/S (DK) | 1994-06-29 | — | — | EP | disclosed |
| WO-1993023418-A1 | PURINE DERIVATIVES | NOVO NORDISK A/S (DK) | 1993-11-25 | — | — | WO | disclosed |