SCHEMBL8910047

SCHEMBL8910047

Fc1cc(/C=N/Nc2nc(Nc3ccc(OC(F)(F)F)cc3)nc(OCC(F)(F)F)n2)ccc1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
LMNA P02545 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
CHRNA7 P36544 8/20 0.39
EGFR P00533 1/20 0.39
MET P08581 1/20 0.39
ROS1 P08922 1/20 0.39
ALK Q9UM73 1/20 0.39
CTSC P53634 1/20 0.39
CA12 O43570 4/20 0.38
CA1 P00915 4/20 0.38
CA2 P00918 4/20 0.38
CA9 Q16790 4/20 0.38
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
DDX3X O00571 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8909365 0.93 MEN1 (0.43) MEN1KMT2ALMNATDP1L3MBTL1
SCHEMBL8908843 0.87 SMN1; SMN2 (0.45) MEN1KMT2ALMNATDP1L3MBTL1
SCHEMBL13883629 0.85 MEN1 (0.44) MEN1KMT2ALMNATDP1L3MBTL1
SCHEMBL8909090 0.84 MEN1 (0.45) MEN1KMT2ALMNATDP1L3MBTL1
SCHEMBL8909394 0.84 TDP1 (0.47) MEN1KMT2ALMNATDP1L3MBTL1
SCHEMBL8910323 0.83 MEN1 (0.44) MEN1KMT2ALMNATDP1L3MBTL1
SCHEMBL8910034 0.82 TDP1 (0.52) MEN1KMT2ALMNATDP1L3MBTL1
SCHEMBL8909208 0.81 MEN1 (0.42) MEN1KMT2ALMNATDP1L3MBTL1
SCHEMBL8908895 0.80 KMT2A (0.55) MEN1KMT2ALMNATDP1L3MBTL1
SCHEMBL13882992 0.79 TDP1 (0.48) MEN1KMT2ALMNATDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8188273-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES, LLC. (US) 2012-05-29 US disclosed
US-8188273-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES, LLC. (US) 2012-05-29 US disclosed
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2012-02-16 US disclosed
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2012-02-16 US disclosed
US-8067588-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES LLC (US) 2011-11-29 US disclosed
US-8067588-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES LLC (US) 2011-11-29 US disclosed
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2009-04-09 US disclosed
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2009-04-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES HELZ, API5, CRYZ MEN1 3633/4885KMT2A 1091/4885LMNA 3505/4885
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES HELZ, API5, CRYZ MEN1 3633/4885KMT2A 1091/4885LMNA 3505/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.