Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | MYC | P01106 | 1/20 | 0.30 |
| ▸ | WDR5 | P61964 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | NSD2 | O96028 | 1/20 | 0.30 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8910135 | 0.82 | PTPN1 (0.32) | S1PR1PTPN1S1PR3SLC22A12 | |
| SCHEMBL8482788 | 0.81 | PTPN1 (0.34) | PTPN1CTSBCTSSCTSKCD274 | |
| SCHEMBL8911110 | 0.79 | LTB4R2 (0.34) | PTPN1CTSBCTSS | |
| SCHEMBL9079126 | 0.73 | S1PR1 (0.35) | S1PR1HDAC1CD274MYCWDR5 | |
| SCHEMBL8485600 | 0.71 | MAOB (0.41) | CD274HDAC6MYCWDR5 | |
| SCHEMBL2200 | 0.71 | MYC (0.45) | S1PR1PTPN1S1PR3CD274CTSD | |
| SCHEMBL8484313 | 0.69 | PPARG (0.33) | S1PR1HDAC1 | |
| SCHEMBL8482925 | 0.67 | ABL1 (0.40) | S1PR1PTPN1S1PR3CD274CTSD | |
| SCHEMBL8487337 | 0.65 | CYP2A6 (0.40) | — | |
| SCHEMBL2226 | 0.64 | MYC (0.46) | S1PR1PTPN1S1PR3CD274CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5620998-A | CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |
| US-5506240-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |