SCHEMBL8910240

SCHEMBL8910240

CCOc1c(C)cnc(CO)c1C

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AGXT P21549 1/20 0.49
HSP90AA1 P07900 7/20 0.43
HSP90AB1 P08238 3/20 0.43
ENPP2 Q13822 1/20 0.36
PDE10A Q9Y233 1/20 0.34
TRAP1 Q12931 2/20 0.33
ATP4A P20648 2/20 0.33
ATP4B P51164 2/20 0.33
SHMT2 P34897 1/20 0.33
WDR5 P61964 1/20 0.33
KMT2A Q03164 1/20 0.33
HSP90B1 P14625 1/20 0.33
BRS3 P32247 1/20 0.33
DDAH1 O94760 1/20 0.33
SARM1 Q6SZW1 1/20 0.33
IDO2 Q6ZQW0 1/20 0.33
ENGASE Q8NFI3 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
GLA P06280 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29382857 0.85 AGXT (0.66) AGXTHSP90AA1HSP90AB1PDE10ATRAP1
SCHEMBL1060082 0.85 AGXT (0.66) AGXTHSP90AA1HSP90AB1PDE10ATRAP1
Hydrochloric Acid SCHEMBL3247161 0.83 AGXT (0.64) AGXTHSP90AA1HSP90AB1PDE10ATRAP1
SCHEMBL8500701 0.81 AGXT (0.45) AGXTHSP90AA1HSP90AB1ENPP2PDE10A
Hydrochloric Acid SCHEMBL9784655 0.80 HSP90AA1 (0.45) AGXTHSP90AA1HSP90AB1ENPP2PDE10A
SCHEMBL3182871 0.80 AGXT (0.44) AGXTHSP90AA1HSP90AB1PDE10ATRAP1
SCHEMBL9793484 0.80 AGXT (0.44) AGXTHSP90AA1HSP90AB1PDE10ATRAP1
SCHEMBL28643701 0.80 SARM1 (0.47) AGXTHSP90AA1HSP90AB1PDE10ATRAP1
SCHEMBL9784656 0.77 AGXT (0.45) AGXTHSP90AA1HSP90AB1ENPP2KMT2A
SCHEMBL9835758 0.77 AGXT (0.42) AGXTHSP90AA1HSP90AB1PDE10ATRAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5616713-A Process of preparing 2-hydroxymethyl-3,5-dimethyl-4-methoxypyridine DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) 1997-04-01 US disclosed
US-4981861-A ANTIULCER HOFFMANN-LA ROCHE INC. (US) 1991-01-01 US disclosed
US-4634710-A ANTIULCER, ANTISECRETORY HOFFMANN-LA ROCHE INC. (US) 1987-01-06 US disclosed