Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.50 |
| ▸ | CHAT | P28329 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.63 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.59 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29620211 | 0.98 | CHAT (0.63) | CHATRAB9APABPC1EIF4HMEN1 | |
| SCHEMBL7994350 | 0.98 | CHAT (0.63) | CHATRAB9APABPC1EIF4HMEN1 | |
| Iodide SCHEMBL11391941 | 0.85 | RAB9A (0.66) | CHATRAB9APABPC1EIF4HMEN1 | |
| Iodide SCHEMBL6858970 | 0.85 | RAB9A (0.61) | CHATRAB9APABPC1EIF4HMEN1 | |
| Iodide SCHEMBL6561260 | 0.85 | RAB9A (0.61) | CHATRAB9APABPC1EIF4HMEN1 | |
| Iodide SCHEMBL11391939 | 0.85 | RAB9A (0.66) | CHATRAB9APABPC1EIF4HMEN1 | |
| SCHEMBL13766057 | 0.85 | RAB9A (0.60) | CHATRAB9APABPC1EIF4HMEN1 | |
| SCHEMBL11591198 | 0.83 | RAB9A (0.59) | CHATRAB9APABPC1EIF4HMEN1 | |
| SCHEMBL10905405 | 0.83 | RAB9A (0.62) | CHATRAB9APABPC1EIF4HMEN1 | |
| SCHEMBL7578852 | 0.83 | RAB9A (0.59) | CHATRAB9APABPC1EIF4HMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0670041-A4 | FLUORESCENCE ENERGY TRANSFER AND INTRAMOLECULAR ENERGY TRANSFER IN PARTICLES USING NOVEL COMPOUNDS. | BIOSITE DIAGNOSTICS INC (US) | 1997-11-05 | — | — | EP | disclosed |
| EP-0670041-A1 | FLUORESCENCE ENERGY TRANSFER AND INTRAMOLECULAR ENERGY TRANSFER IN PARTICLES USING NOVEL COMPOUNDS | BIOSITE DIAGNOSTICS INC. (US) | 1995-09-06 | — | — | EP | disclosed |
| WO-1995008772-A1 | FLUORESCENCE ENERGY TRANSFER AND INTRAMOLECULAR ENERGY TRANSFER IN PARTICLES USING NOVEL COMPOUNDS | BIOSITE DIAGNOSTICS INCORPORATED (US) | 1995-03-30 | — | — | WO | disclosed |
| US-5292888-A | High melting point stilbazolium salts | GENERAL ELECTRIC COMPANY (US) | 1994-03-08 | — | — | US | disclosed |