SCHEMBL8911523

SCHEMBL8911523

COc1ccc(C([C]=O)c2ccc(OC)c(OC)c2)cc1OC

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.48
ACHE P22303 6/20 0.47
CA1 P00915 2/20 0.47
CA2 P00918 2/20 0.47
PPARG P37231 1/20 0.47
PPARD Q03181 1/20 0.47
PPARA Q07869 1/20 0.47
L3MBTL1 Q9Y468 2/20 0.46
CYP1A2 P05177 2/20 0.46
CYP2C9 P11712 2/20 0.46
CYP2C19 P33261 2/20 0.46
KMT2A Q03164 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
ALDH1A1 P00352 4/20 0.44
TSHR P16473 4/20 0.44
RAB9A P51151 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
CA12 O43570 1/20 0.43
CA7 P43166 1/20 0.43
CA9 Q16790 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6531274 0.83 ALDH1A1 (0.44) L3MBTL1CYP2C9CYP2C19KMT2ANPSR1
SCHEMBL910620 0.82 ACHE (0.50) ACHECA1CA2PPARGPPARD
SCHEMBL9181573 0.81 CYP1A2 (0.40) ATMACHECA1CA2PPARG
SCHEMBL9781892 0.81 ACHE (0.45) ACHECA1CA2PPARGPPARD
SCHEMBL13955907 0.76 PPARG (0.55) ACHECA1CA2PPARGPPARD
SCHEMBL11304731 0.75 ACHE (0.44) ACHECA1CA2PPARGPPARD
SCHEMBL5373513 0.75 ALDH1A1 (0.47) ACHECA1CA2PPARGPPARD
SCHEMBL10608754 0.75 ACHE (0.54) ACHECA1CA2PPARGPPARD
SCHEMBL5110084 0.74 ACHE (0.50) ACHECA1CA2PPARGPPARD
SCHEMBL84033 0.74 PPARG (0.53) ACHECA1CA2PPARGPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5622953-A DRUG RESISTANT TO ANTICANCER CHEMOTHERAPEUTIC DRUG BASF AKTIENGESELLSCHAFT (DE) 1997-04-22 US disclosed
EP-0691962-A1 1-AMINO-3-PHENOXY PROPANE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE BASF AKTIENGESELLSCHAFT (DE) 1996-01-17 EP disclosed
WO-1994022842-A1 1-AMINO-3-PHENOXY PROPANE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE BASF AKTIENGESELLSCHAFT (DE) 1994-10-13 WO disclosed