SCHEMBL8911652

SCHEMBL8911652

CCOC(=O)c1[nH]c(COC(C)=O)c(C(C)=O)c1CC

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.44
CYP2C19 P33261 3/20 0.44
CYP2C9 P11712 2/20 0.44
ALDH1A1 P00352 5/20 0.43
MAPK1 P28482 1/20 0.43
IGF1R P08069 1/20 0.43
XBP1 P17861 1/20 0.42
HPGD P15428 2/20 0.42
BRD4 O60885 1/20 0.41
BRPF1 P55201 1/20 0.41
EP300 Q09472 1/20 0.41
CREBBP Q92793 1/20 0.41
ALOX15 P16050 1/20 0.40
POLB P06746 3/20 0.40
TSHR P16473 2/20 0.40
NPSR1 Q6W5P4 2/20 0.40
KDM4E B2RXH2 2/20 0.40
CASP1 P29466 1/20 0.40
KMT2A Q03164 2/20 0.39
RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7962367 0.85 HPGD (0.55) CYP1A2CYP2C19CYP2C9ALDH1A1MAPK1
SCHEMBL8204552 0.80 BRD4 (0.62) CYP1A2CYP2C19CYP2C9ALDH1A1MAPK1
SCHEMBL8909803 0.75 CYP1A2 (0.52) CYP1A2ALDH1A1MAPK1XBP1HPGD
SCHEMBL11648083 0.75 CYP1A2 (0.55) CYP1A2CYP2C19CYP2C9ALDH1A1MAPK1
SCHEMBL12050225 0.74 NPC1 (0.56) CYP1A2CYP2C19CYP2C9ALDH1A1MAPK1
SCHEMBL11647620 0.73 CYP1A2 (0.58) CYP1A2CYP2C19CYP2C9ALDH1A1MAPK1
SCHEMBL8716863 0.70 RAB9A (0.63) ALDH1A1MAPK1HPGDPOLBTSHR
SCHEMBL11648233 0.70 CYP1A2 (0.62) CYP1A2CYP2C19CYP2C9ALDH1A1MAPK1
SCHEMBL11650167 0.70 CYP1A2 (0.53) CYP1A2CYP2C19CYP2C9ALDH1A1MAPK1
SCHEMBL11649200 0.70 CYP1A2 (0.67) CYP1A2CYP2C19CYP2C9ALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5679694-A LOW TOXICITY AGAINST NORMAL CELL LINES THE WELLCOME FOUNDATION LTD. (GB) 1997-10-21 US disclosed
EP-0651750-A1 TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS THE WELLCOME FOUNDATION LIMITED (GB) 1995-05-10 EP disclosed
WO-1994002483-A1 TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS THE WELLCOME FOUNDATION LIMITED (GB) 1994-02-03 WO disclosed