Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | ADA | P00813 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.35 |
| ▸ | CNR2 | P34972 | 4/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | PLK1 | P53350 | 3/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.33 |
| ▸ | CDC25B | P30305 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015254 | 0.78 | — | — | |
| SCHEMBL668253 | 0.69 | ASAH1 (0.51) | AGTR1AGTR2ADA | |
| SCHEMBL9091629 | 0.64 | AGTR1 (0.77) | AGTR1AGTR2PTPN1PLK1PLK3 | |
| SCHEMBL9092112 | 0.62 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL7020223 | 0.62 | PTPN11 (0.43) | AGTR1AGTR2PTPN11 | |
| SCHEMBL24476294 | 0.62 | P2RX7 (0.41) | ADA | |
| SCHEMBL24476401 | 0.62 | P2RX7 (0.41) | ADA | |
| SCHEMBL7016171 | 0.62 | — | — | |
| SCHEMBL9091837 | 0.62 | AGTR1 (0.82) | AGTR1AGTR2PLK1 | |
| Hydrochloric Acid SCHEMBL9087410 | 0.61 | AGTR1 (0.58) | AGTR1AGTR2PTPN1PLK1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5612360-A | AROMATIC N-HETEROCYCLIC COMPOUNDS AS HYPOTENSIVE AGENTS WITH ACID GROUPS, SULFONYLCARBOXAMIDES OR TETRAZOLE GROUPS | ELI LILLY AND COMPANY (US) | 1997-03-18 | — | — | US | disclosed |