Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 6/20 | 0.64 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8503079 | 0.87 | TACR1 (0.61) | TACR1HTR2CDRD2HTR2AHTR2B | |
| SCHEMBL8502905 | 0.87 | TACR1 (0.61) | TACR1HTR2CDRD2HTR2AHTR2B | |
| SCHEMBL22816111 | 0.81 | HTR2C (0.57) | TACR1HTR2CDRD2HTR2AHTR2B | |
| SCHEMBL8504929 | 0.80 | TACR1 (0.49) | TACR1HTR2CDRD2 | |
| SCHEMBL8907338 | 0.80 | HTR2C (0.52) | TACR1HTR2CDRD2HTR2AHTR2B | |
| SCHEMBL8907343 | 0.77 | TACR1 (0.49) | TACR1HTR2CDRD2HTR2AHTR2B | |
| SCHEMBL1065758 | 0.71 | HTR2C (0.77) | HTR2CDRD2HTR2AHTR2BHTR1A | |
| SCHEMBL744072 | 0.70 | RAB9A (0.37) | TACR1DRD2HTR2AHTR1AKDM1A | |
| SCHEMBL22816650 | 0.69 | HTR2C (0.53) | TACR1HTR2CKDM1ARCOR1 | |
| SCHEMBL2427723 | 0.68 | HTR2C (0.58) | TACR1HTR2CDRD2HTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799231-A1 | SPIROKETAL DERIVATIVES, COMPOSITIONS CONTAINING THEM AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1997-10-08 | — | — | EP | claimed |