Sugi Predict

Sugi Predict / Compounds / SCHEMBL1065758

SCHEMBL1065758

SCHEMBL1065758

FC(F)(F)c1cccc(C2CC2)c1

nearest known ligand 0.77

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ HTR2C P28335 4/20 0.77
▸ DRD2 P14416 2/20 0.62
▸ HTR2A P28223 2/20 0.51
▸ HTR2B P41595 2/20 0.51
▸ HTR1A P08908 1/20 0.49
▸ KDM1A O60341 1/20 0.47
▸ RCOR1 Q9UKL0 1/20 0.47
▸ TRPV6 Q9H1D0 1/20 0.47
▸ DRD4 P21917 1/20 0.47
▸ GRM2 Q14416 1/20 0.47
▸ TSHR P16473 1/20 0.47
▸ MAPK1 P28482 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cyanide SCHEMBL27792102 0.94 HTR2C (0.70) HTR2CDRD2HTR2AHTR2BHTR1A
SCHEMBL2532290 0.92 HTR2C (0.72) HTR2CDRD2HTR2AHTR2BHTR1A
SCHEMBL16457233 0.92 HTR2C (0.72) HTR2CDRD2HTR2AHTR2BHTR1A
SCHEMBL15336102 0.91 HTR2C (0.66) HTR2CDRD2HTR2AHTR2BKDM1A
SCHEMBL22816107 0.91 HTR2C (0.66) HTR2CDRD2HTR2AHTR2BHTR1A
SCHEMBL13197434 0.91 HTR2C (0.66) HTR2CDRD2HTR2AHTR2BHTR1A
SCHEMBL13197435 0.91 HTR2C (0.66) HTR2CDRD2HTR2AHTR2BHTR1A
SCHEMBL5668848 0.90 HTR2C (0.70) HTR2CDRD2HTR2AHTR2B
SCHEMBL31087548 0.90 HTR2C (0.70) HTR2CDRD2HTR2AHTR2B
Hydrochloric Acid SCHEMBL16536318 0.89 HTR2C (0.67) HTR2CDRD2HTR2AHTR2BKDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3814332-B1 PESTICIDALLY ACTIVE AZOLE-AMIDE COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2023-06-07 — — EP disclosed
US-20230143596-A1 PESTICIDALLY ACTIVE DIAZINE-BISAMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-05-11 — — US disclosed
US-20220213063-A1 N-[l-(5-BROMO-2-PYRIMIDIN-2-YL-1,2,4-TRIAZOL-3-YL)ETHYL]-2-CYCLOPROPYL-6-(TRIFLUOROMETHYL)PYRIDINE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INSECTICIDES SYNGENTA CROP PROTECTION AG (CH) 2022-07-07 — — US disclosed
US-20220185789-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-06-16 — — US disclosed
US-20220167618-A1 PESTICIDALLY ACTIVE AZOLE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-06-02 — — US disclosed
US-20220159958-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-05-26 — — US disclosed
WO-2020201079-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-08 — — WO disclosed
WO-2020002563-A1 PESTICIDALLY ACTIVE AZOLE-AMIDE COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2020-01-02 — — WO disclosed
CN-110072842-A Molecules having pesticidal utility, and intermediates, compositions and methods related thereto 美国陶氏益农公司 2019-07-30 — — CN disclosed
US-20170001983-A1 TRPA1 MODULATORS ALGOMEDIX, INC. 2017-01-05 — — US disclosed
EP-2277869-A1 Cycloalkylamidbenzoxa(thia)zoles as fungicides Bayer CropScience AG (DE) 2011-01-26 — — EP disclosed
EP-2134692-A2 QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION Wyeth a Corporation of the State of Delaware (US) 2009-12-23 — — EP disclosed
US-20090239910-A1 Benzenesulfonamide Compounds and Their Use EURO-CELTIQUE S.A. (LU) 2009-09-24 — — US disclosed
US-20080255192-A1 2-(1-(4-chlorophenyl)cyclopropyl)-3-hydroxy-8-(trifluoromethoxy)quinoline-4-carboxylic acid; antiinflammtory agents; antagonists of the mammalian adhesion proteins WYETH (US) 2008-10-16 — — US disclosed
WO-2008121817-A2 QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION WYETH (US) 2008-10-09 — — WO disclosed
EP-0832073-B1 QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS SUGEN INC (US) 2002-01-16 — — EP disclosed
EP-0618193-B1 Nitrogen containing bicyclic derivatives as prolyl-endopeptidase inhibitors ADIR (FR) 1998-10-21 — — EP disclosed
US-5051447-A Applying aromatic oximes to plants, seeds or soils BASF AKTIENGESELLSCHAFT (DE) 1991-09-24 — — US disclosed
US-4952720-A Ortho-substituted benzyl carboxylates and fungicides which contain these compounds BASF AKTIENGSELLSCHAFT (DE) 1990-08-28 — — US disclosed
US-4859232-A Substituted-aryl cyclopropanecarbonitriles and derivatives thereof as herbicide antidotes MONSANTO COMPANY (US) 1989-08-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170001983-A1 TRPA1 MODULATORS TRPA1, TRPV1, TRPV2 HTR2C 75/4885DRD2 1062/4885HTR2A 73/4885
US-20230143596-A1 PESTICIDALLY ACTIVE DIAZINE-BISAMIDE COMPOUNDS DDT, ACHE, NIT2 HTR2C 1064/4885DRD2 854/4885HTR2A 1250/4885
US-20220167618-A1 PESTICIDALLY ACTIVE AZOLE-AMIDE COMPOUNDS DDT, ACHE, CYP51A1 HTR2C 2872/4885DRD2 3995/4885HTR2A 3886/4885
US-20220185789-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS DDT, ACHE, NIT2 HTR2C 2055/4885DRD2 1723/4885HTR2A 2421/4885
US-20080255192-A1 2-(1-(4-chlorophenyl)cyclopropyl)-3-hydroxy-8-(trifluoromethoxy)quinoline-4-carboxylic acid; antiinflammtory agents; antagonists of the mammalian adhesion proteins VCAM1, ICAM1, SELE HTR2C 661/4885DRD2 2187/4885HTR2A 627/4885
US-20090239910-A1 Benzenesulfonamide Compounds and Their Use CACNA1E, CACNA1A, KCNN3 HTR2C 428/4885DRD2 203/4885HTR2A 561/4885
US-20220213063-A1 N-[l-(5-BROMO-2-PYRIMIDIN-2-YL-1,2,4-TRIAZOL-3-YL)ETHYL]-2-CYCLOPROPYL-6-(TRIFLUOROMETHYL)PYRIDINE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INSECTICIDES DDT, CYP2E1, CYP4B1 HTR2C 250/4885DRD2 733/4885HTR2A 950/4885
US-20220159958-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS DDT, ACHE, NIT2 HTR2C 1976/4885DRD2 2051/4885HTR2A 2260/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.