Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 6/20 | 0.46 |
| ▸ | PPARG | P37231 | 5/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6443317 | 0.89 | PPARA (0.48) | PPARAPPARGCTSSCTSKALDH1A1 | |
| SCHEMBL12070284 | 0.88 | CTSK (0.51) | PPARAPPARGCTSSCTSKATM | |
| SCHEMBL7087412 | 0.88 | CTSK (0.51) | PPARAPPARGCTSSCTSKATM | |
| SCHEMBL144832 | 0.88 | CTSK (0.51) | PPARAPPARGCTSSCTSKATM | |
| SCHEMBL13363641 | 0.88 | CTSK (0.51) | PPARAPPARGCTSSCTSKATM | |
| SCHEMBL335777 | 0.88 | CTSK (0.51) | PPARAPPARGCTSSCTSKATM | |
| SCHEMBL767076 | 0.88 | CTSK (0.51) | PPARAPPARGCTSSCTSKATM | |
| SCHEMBL6166 | 0.88 | CTSK (0.51) | PPARAPPARGCTSSCTSKATM | |
| SCHEMBL8886861 | 0.88 | CTSK (0.51) | PPARAPPARGCTSSCTSKATM | |
| SCHEMBL7625656 | 0.87 | MAPT (0.46) | PPARAPPARGCTSSCTSKATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024299-A2 | COMBINATION WITH BIS(THIOHYDRAZIDE AMIDES) FOR TREATING CANCER | SYNTA PHARMACEUTICALS CORP. (US) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008024305-A2 | BIS (THIOHYDRAZIDE AMIDES) FOR TREATING MELANOMA | SYNTA PHARMACEUTICALS CORP. (US) | 2008-02-28 | — | — | WO | disclosed |
| US-5606068-A | Acid anhydrides, their preparation and their use | RHONE-POULENC RORER S.A. (FR) | 1997-02-25 | — | — | US | disclosed |
| US-5476954-A | Condensing hydroxyl protected taxane derivative with oxazolidine derivative, decyclizing in acid medium, reacting butoxycarbonyl or benzoyl radical with amine, deprotecting, isolating, purifying product | RHONE-POULENC RORER S.A. (FR) | 1995-12-19 | — | — | US | disclosed |