SCHEMBL8912154

SCHEMBL8912154

CC1(C)CC[Si](C)(CCCCCc2ccc(C(=O)Oc3ccc(C#N)cc3)cc2)[Si](C)(C)O1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F2 P00734 1/20 0.37
PLA2G4A P47712 1/20 0.34
RAB9A P51151 1/20 0.34
TSHR P16473 4/20 0.34
CYP1A2 P05177 2/20 0.34
CYP2D6 P10635 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
ALDH1A1 P00352 2/20 0.34
USP2 O75604 2/20 0.34
CYP2C9 P11712 2/20 0.34
HIF1A Q16665 1/20 0.34
MGLL Q99685 2/20 0.33
CYP3A4 P08684 2/20 0.33
PRSS1 P07477 1/20 0.33
ACR P10323 1/20 0.33
HSD17B10 Q99714 1/20 0.33
MAPT P10636 4/20 0.33
THRA P10827 1/20 0.33
THRB P10828 1/20 0.33
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8914086 0.96 F2 (0.38) F2PLA2G4ARAB9ATSHRCYP1A2
SCHEMBL9303232 0.89 SMN1; SMN2 (0.41) PLA2G4ASMN1; SMN2ALDH1A1PRSS1ACR
SCHEMBL8913271 0.89 SMN1; SMN2 (0.41) PLA2G4ASMN1; SMN2ALDH1A1PRSS1ACR
SCHEMBL8913315 0.88 MAPT (0.41) CYP1A2CYP2D6SMN1; SMN2CYP2C9CYP3A4
SCHEMBL8913744 0.85 MAPT (0.39) F2RAB9ACYP1A2CYP2D6SMN1; SMN2
SCHEMBL9304072 0.84 PRSS1 (0.43) RAB9ATSHRCYP1A2CYP2D6SMN1; SMN2
SCHEMBL8913606 0.83 RARB (0.41) TSHRALDH1A1MGLLHSD17B10MAPT
SCHEMBL8913896 0.81 PTGDR2 (0.36)
SCHEMBL16848610 0.78 F2 (0.52) F2RAB9ATSHRCYP1A2CYP2D6
SCHEMBL16848602 0.78 F2 (0.52) F2RAB9ATSHRCYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE35462-E Silylated benzoic acid derivatives CONSORTIUM FUR ELEKOCHEMISCHE IND. GMBH (DE) 1997-02-25 US disclosed
US-5277838-A Silylated benzoic acid derivatives CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1994-01-11 US disclosed
US-5106530-A Liquid crystals Consortium Fur Elektrochemische Ind. (DE) 1992-04-21 US disclosed