Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8912244 | 0.86 | SMN1; SMN2 (0.61) | SMN1; SMN2CYP1A2CYP2C9CYP2C19RAB9A | |
| SCHEMBL9571758 | 0.81 | NPC1 (0.46) | SMN1; SMN2CYP1A2CYP2C9CYP2C19RAB9A | |
| SCHEMBL26527665 | 0.80 | MAPK1 (0.50) | SMN1; SMN2CYP1A2CYP2C9CYP2C19RAB9A | |
| SCHEMBL10675936 | 0.80 | CYP1A2 (1.00) | SMN1; SMN2CYP1A2CYP2C9CYP2C19RAB9A | |
| SCHEMBL20579849 | 0.79 | RAB9A (0.82) | SMN1; SMN2CYP1A2CYP2C9CYP2C19RAB9A | |
| SCHEMBL8910901 | 0.79 | NPC1 (1.00) | SMN1; SMN2CYP1A2CYP2C9CYP2C19RAB9A | |
| SCHEMBL20579811 | 0.78 | NPC1 (0.80) | SMN1; SMN2CYP1A2CYP2C9CYP2C19RAB9A | |
| SCHEMBL20579837 | 0.78 | SMN1; SMN2 (0.74) | SMN1; SMN2CYP1A2CYP2C9CYP2C19RAB9A | |
| SCHEMBL20579809 | 0.78 | CYP1A2 (0.78) | SMN1; SMN2CYP1A2CYP2C9CYP2C19RAB9A | |
| SCHEMBL20579803 | 0.77 | RAB9A (0.79) | SMN1; SMN2CYP1A2CYP2C9CYP2C19RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5635525-A | DIAGNOSTICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-06-03 | — | — | US | disclosed |
| US-5444068-A | Imidazopyridine derivatives as angiotensin II receptor antagonists, pharmaceuticals, and treatment of hypertension therewith | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-08-22 | — | — | US | disclosed |
| US-5440046-A | Angiotensin antagonist, hypotensive agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-08-08 | — | — | US | disclosed |
| US-5350751-A | Hypotensive agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-09-27 | — | — | US | disclosed |