Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMKLR1 | Q99788 | 4/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.44 |
| ▸ | GCGR | P47871 | 2/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8911829 | 0.92 | CMKLR1 (0.44) | CMKLR1AGTR1AGTR2 | |
| SCHEMBL8931840 | 0.80 | CMKLR1 (0.45) | CMKLR1AGTR1AGTR2CXCR4 | |
| SCHEMBL8912814 | 0.80 | GCGR (0.43) | GCGR | |
| SCHEMBL7017865 | 0.77 | AGTR1 (0.48) | AGTR1AGTR2 | |
| SCHEMBL7020436 | 0.76 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL7019155 | 0.74 | AGTR1 (0.45) | AGTR1AGTR2 | |
| SCHEMBL19922853 | 0.73 | GCGR (0.59) | GCGR | |
| SCHEMBL7020684 | 0.72 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL7019881 | 0.72 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL7020676 | 0.72 | AGTR1 (0.46) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5612360-A | AROMATIC N-HETEROCYCLIC COMPOUNDS AS HYPOTENSIVE AGENTS WITH ACID GROUPS, SULFONYLCARBOXAMIDES OR TETRAZOLE GROUPS | ELI LILLY AND COMPANY (US) | 1997-03-18 | — | — | US | disclosed |
| US-5569768-A | USEFUL IN TREATING HYPERTENSION, CONGESTIVE HEART FAILURE, GLAUCOMA AND RENAL INSUFFICIENCY | ELI LILLY AND COMPANY (US) | 1996-10-29 | — | — | US | disclosed |
| US-5556981-A | Angiotensin II antagonist intermediates | ELI LILLY AND COMPANY (US) | 1996-09-17 | — | — | US | disclosed |
| EP-0574174-A2 | Angiotensin II antagonists | ELI LILLY AND COMPANY (US) | 1993-12-15 | — | — | EP | disclosed |