Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 3/20 | 0.52 |
| ▸ | PRKCG | P05129 | 3/20 | 0.52 |
| ▸ | PRKCB | P05771 | 3/20 | 0.52 |
| ▸ | PRKCA | P17252 | 3/20 | 0.52 |
| ▸ | PRKCH | P24723 | 3/20 | 0.52 |
| ▸ | PRKCI | P41743 | 3/20 | 0.52 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.52 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.52 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.52 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.52 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8914464 | 0.88 | PRKD3 (0.56) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Iodide SCHEMBL8914720 | 0.84 | PRKD3 (0.52) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Iodide SCHEMBL8912408 | 0.84 | APOBEC3A (0.40) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Iodide SCHEMBL8913483 | 0.81 | PABPC1 (0.45) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL10379483 | 0.80 | PABPC1 (0.43) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Iodide SCHEMBL8912933 | 0.78 | PRKD3 (0.44) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Iodide SCHEMBL8912433 | 0.74 | CDC25A (0.47) | CDC25ATHRB | |
| Iodide SCHEMBL8913681 | 0.74 | CDC25A (0.47) | CDC25A | |
| Iodide SCHEMBL8913654 | 0.74 | CDC25A (0.47) | CDC25A | |
| Iodide SCHEMBL8913646 | 0.72 | PRKCA (0.41) | PRKD3PRKCGPRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614548-A | TREATING TUMORS AND HIV INFECTION, PROTEIN KINASE C INHIBITORS | WAKE FOREST UNIVERSITY (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1990004918-A2 | QUATERNARY AMINE CONTAINING ETHER OR ESTER LIPID DERIVATIVES AND THERAPEUTIC COMPOSITIONS | WAKE FOREST UNIVERSITY (US) | 1990-05-17 | — | — | WO | disclosed |