SCHEMBL8912387

SCHEMBL8912387

COc1cccc(C(Cc2ccccc2)C(=O)COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1

nearest known ligand 0.49

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 15/20 0.49
CACNA1F O60840 3/20 0.46
CACNA1D Q01668 3/20 0.46
CACNA1S Q13698 3/20 0.46
CACNA1C Q13936 3/20 0.46
MTNR1A P48039 2/20 0.45
MTNR1B P49286 2/20 0.45
TACR2 P21452 1/20 0.45
PPARG P37231 1/20 0.43
PPARA Q07869 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8910807 0.86 TACR1 (0.48) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8910805 0.86 TACR1 (0.48) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL9540662 0.78 TACR1 (0.52) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8910652 0.77 TACR1 (0.60) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8963934 0.77 TACR1 (0.59) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7041441 0.75 MTNR1A (0.61) MTNR1AMTNR1BPPARGPPARA
SCHEMBL27555215 0.74 MTNR1A (0.63) MTNR1AMTNR1BPPARGPPARA
SCHEMBL29609868 0.73 EPHX1 (0.65) MTNR1AMTNR1B
SCHEMBL28617579 0.73 EPHX1 (0.65) MTNR1AMTNR1B
SCHEMBL7042372 0.73 MTNR1A (0.62) MTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5629347-A TACHYKININ ANTAGONIST USED IN TREATMENT OF INFLAMMATION, MIGRAINE, POSTHERPETIC NEURALGIA MERCK SHARP & DOHME LTD. (GB) 1997-05-13 US disclosed
EP-0593557-B1 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY MERCK SHARP & DOHME (GB) 1996-01-31 EP disclosed
WO-1993001160-A1 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY MERCK SHARP & DOHME LIMITED (GB) 1993-01-21 WO disclosed
EP-0522808-A2 Aromatic compounds, pharmaceutical compositions containing them and their use in therapy MERCK SHARP & DOHME LTD. (GB) 1993-01-13 EP disclosed