SCHEMBL9540662

SCHEMBL9540662

COc1cccc(C(CCOCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)Cc2ccccc2)c1

nearest known ligand 0.52

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 14/20 0.52
CACNA1F O60840 2/20 0.48
CACNA1D Q01668 2/20 0.48
CACNA1S Q13698 2/20 0.48
CACNA1C Q13936 2/20 0.48
MTNR1A P48039 2/20 0.47
MTNR1B P49286 2/20 0.47
CASR P41180 1/20 0.41
ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8910652 0.79 TACR1 (0.60) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8912387 0.78 TACR1 (0.49) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8910805 0.77 TACR1 (0.48) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8910807 0.77 TACR1 (0.48) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL26152585 0.75 MTNR1A (0.61) MTNR1AMTNR1BCASRALDH1A1
SCHEMBL5311110 0.71 MTNR1A (0.62) MTNR1AMTNR1BCASRALDH1A1
SCHEMBL11420812 0.70 TACR1 (0.56) TACR1CASR
SCHEMBL19210357 0.70 ALDH1A1 (0.73) MTNR1AMTNR1BALDH1A1
Hydrochloric Acid SCHEMBL11418373 0.69 TACR1 (0.55) TACR1CASR
SCHEMBL9317425 0.69 TACR1 (0.57) TACR1CACNA1FCACNA1DCACNA1SCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993001160-A1 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY MERCK SHARP & DOHME LIMITED (GB) 1993-01-21 WO disclosed