Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL661463 | 0.67 | CYP3A4 (0.46) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL377133 | 0.65 | KDM4E (0.39) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL558212 | 0.65 | KDM4E (0.39) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL3195052 | 0.65 | CYP3A4 (0.40) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL7367379 | 0.65 | CYP2A6 (0.38) | CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6 | |
| SCHEMBL2733130 | 0.65 | PDPK1 (0.38) | ALDH1A1CYP2A6HSD17B10RAB9A | |
| SCHEMBL1706101 | 0.65 | — | — | |
| SCHEMBL16291133 | 0.65 | L3MBTL1 (0.57) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL3545 | 0.65 | L3MBTL1 (0.57) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL8585255 | 0.63 | CHRM2 (0.36) | ALDH1A1HPGDMAPTCYP2A6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 286 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102869256-A | Catechol O-methyltransferase inhibitors and their use in the treatment of psychotic disorders | MERCK SHARP & DOHME | 2013-01-09 | — | — | CN | claimed |
| CN-102459210-A | Arylsulfonamide ccr3 antagonists | AXIKIN PHARMACEUTICALS INC | 2012-05-16 | — | — | CN | claimed |
| JP-4829449-B2 | — | — | 2011-12-07 | — | — | JP | claimed |
| US-20100137275-A1 | TRIAMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF CDC25 PHOSPHATASE | IPSEN PHARMA S.A.S. (FR) | 2010-06-03 | — | — | US | claimed |
| CN-101687791-A | 5-lipoxygenase-activating protein (flap) inhibitors | AMIRA PHARMACEUTICALS INC | 2010-03-31 | — | — | CN | claimed |
| CN-101353320-A | Matrix metalloprotease inhibitors, medicinal composition containing the same, preparation and use thereof | POISON MED INST PLA MED ACAD (CN) | 2009-01-28 | — | — | CN | claimed |
| CN-101331117-A | 5-lipoxygenase-activating protein (FLAP) inhibitors | AMIRA PHARMACEUTICALS INC (US) | 2008-12-24 | — | — | CN | claimed |
| JP-2008542433-A | — | — | 2008-11-27 | — | — | JP | claimed |
| EP-1896472-A1 | ALPHA-CARBOLINES AS CDK-1 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2008-03-12 | — | — | EP | claimed |
| CN-101087778-A | Pyrrolidinyl derivatives of heteroaromatic compounds as phosphodiesterase inhibitors | PFIZER (US) | 2007-12-12 | — | — | CN | claimed |
| WO-2006131552-A1 | ALPHA-CARBOLINES AS CDK-1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-12-14 | — | — | WO | claimed |
| CN-1798742-A | Novel biaromatic compounds which activate ppar [upsilon] pharmaceutical compsns | GALDERMA RES & DEV (FR) | 2006-07-05 | — | — | CN | claimed |
| CN-1723193-A | Novel polycyclic compounds which modulate PPARgamma type receptors and cosmetic/pharmaceutical compositions comprised thereof | GALDERMA RES & DEV (FR) | 2006-01-18 | — | — | CN | claimed |
| CN-1711239-A | Novel biaromatic compounds which activate PPARy type receptors and cosmetic/pharmaceutical compositions comprised thereof | GALDERMA RES & DEV (FR) | 2005-12-21 | — | — | CN | claimed |
| CN-1688550-A | 2, 5-dioxoimidazolidin-4-yl acetamides and analogs as metalloproteinase MMP12 inhibitors | ASTRAZENECA AB (SE) | 2005-10-26 | — | — | CN | claimed |
| EP-0833622-B1 | COMPOSITIONS COMPRISING A CYCLOOXYGENASE-2 INHIBITOR AND A 5-LIPOXYGENASE INHIBITOR | SEARLE & CO (US) | 2005-08-10 | — | — | EP | claimed |
| JP-2003508353-A | — | — | 2003-03-04 | — | — | JP | claimed |
| EP-1208097-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | Aventis Pharmaceuticals Inc. (US) | 2002-05-29 | — | — | EP | claimed |
| WO-2001007436-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-02-01 | — | — | WO | claimed |
| EP-0274259-B1 | New renin-inhibitory oligopeptides, their preparaton and their use | SANKYO CO (JP) | 1994-02-16 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137275-A1 | TRIAMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF CDC25 PHOSPHATASE | CDC25A, CDC25B, CDC25C | KDM4E 2170/4885ALDH1A1 2179/4885HPGD 859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.