Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 17/20 | 0.79 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.79 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.79 |
| ▸ | BCHE | P06276 | 8/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL954996 | 0.88 | ACHE (1.00) | ACHEHTR4SIGMAR1BCHEMAPK14 | |
| Fumaric Acid SCHEMBL9208797 | 0.80 | ACHE (0.91) | ACHEHTR4SIGMAR1BCHE | |
| Fumaric Acid SCHEMBL9208786 | 0.80 | ACHE (0.91) | ACHEHTR4SIGMAR1BCHE | |
| Fumaric Acid SCHEMBL9200183 | 0.79 | ACHE (0.91) | ACHE | |
| Fumaric Acid SCHEMBL9206740 | 0.79 | ACHE (0.91) | ACHE | |
| Fumaric Acid SCHEMBL9200177 | 0.79 | ACHE (0.91) | ACHE | |
| Fumaric Acid SCHEMBL9206750 | 0.79 | ACHE (0.91) | ACHE | |
| Fumaric Acid SCHEMBL9207004 | 0.78 | ACHE (0.79) | ACHEBCHE | |
| Fumaric Acid SCHEMBL9209039 | 0.78 | ACHE (0.91) | ACHEBCHE | |
| Fumaric Acid SCHEMBL9209035 | 0.78 | ACHE (0.91) | ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686466-A | CHOLINESERASE INHIBITOR; TREATMENT OF SENILE DEMENTIA, ALZHEIMER'S DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-11-11 | — | — | US | disclosed |