Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | CCR3 | P51677 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18123311 | 0.82 | POLB (0.65) | OPRL1CYP3A4HSD17B10POLBSIGMAR1 | |
| SCHEMBL28548988 | 0.82 | OPRL1 (0.71) | OPRL1CYP3A4HSD17B10POLBSIGMAR1 | |
| SCHEMBL1366704 | 0.81 | OPRL1 (0.65) | OPRL1CYP3A4HSD17B10POLBSIGMAR1 | |
| SCHEMBL7852661 | 0.80 | SIGMAR1 (0.63) | OPRL1CYP3A4HSD17B10POLBSIGMAR1 | |
| SCHEMBL1290790 | 0.79 | OPRL1 (0.58) | OPRL1CYP3A4HSD17B10POLBSIGMAR1 | |
| SCHEMBL1973357 | 0.79 | OPRL1 (0.58) | OPRL1CYP3A4HSD17B10POLBSIGMAR1 | |
| SCHEMBL1269135 | 0.79 | OPRL1 (0.58) | OPRL1CYP3A4HSD17B10POLBSIGMAR1 | |
| SCHEMBL2789160 | 0.78 | OPRL1 (0.66) | OPRL1CYP3A4HSD17B10POLBSIGMAR1 | |
| SCHEMBL5995214 | 0.78 | POLB (0.77) | OPRL1POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL16579984 | 0.77 | KMT2A (0.65) | OPRL1CYP3A4HSD17B10POLBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808303-A1 | 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024582-A1 | 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1996-08-15 | — | — | WO | disclosed |