SCHEMBL8913308

SCHEMBL8913308

O=C(Cl)c1c(C(=O)Cl)c(C(=O)Cl)c(C(=O)Cl)c(C(=O)Cl)c1C(=O)Cl

nearest known ligand 0.47

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.47
TSHR P16473 1/20 0.31
ALOX15 P16050 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9407785 0.84 ALDH1A1 (0.39) ALDH1A1TSHR
SCHEMBL9290781 0.84 ALDH1A1 (0.39) ALDH1A1TSHR
SCHEMBL6516188 0.82 ALDH1A1 (0.38) ALDH1A1
SCHEMBL6512705 0.79 ALDH1A1 (0.36) ALDH1A1
SCHEMBL6517326 0.79 ALDH1A1 (0.36) ALDH1A1
SCHEMBL6512990 0.79 ALDH1A1 (0.36) ALDH1A1
SCHEMBL15065243 0.79 ALDH1A1 (0.36) ALDH1A1
SCHEMBL2295038 0.79 ALDH1A1 (0.48) ALDH1A1
SCHEMBL103420 0.79 ALDH1A1 (0.48) ALDH1A1
SCHEMBL4163347 0.76 ALDH1A1 (0.39) ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0229470-B1 BRANCHED COPOLYETHERKETONES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-01-30 EP claimed
US-4720537-A Branched copolyetherketones E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-01-19 US claimed
EP-0229470-A1 Branched copolyetherketones E.I. DU PONT DE NEMOURS AND COMPANY (US) 1987-07-22 EP claimed
CN-110317322-B Particulate amine-functionalized polyaryletherketone polymers and copolymers thereof 塞特工业公司 2022-06-14 CN disclosed
EP-3145975-B1 AMINE-DERIVATISED POLYARYLETHERKETONE COPOLYMERS KETONEX LTD (GB) 2021-03-17 EP disclosed
US-10800876-B2 Amine and non-amine derivatized polyaryletherketone random and block copolymers KETONEX LIMITED (GB) 2020-10-13 US disclosed
EP-3145980-B1 PARTICULATE AMINE-FUNCTIONALIZED POLYARYLETHERKETONE POLYMER AND COPOLYMERS THEREOF CYTEC IND INC (US) 2020-04-08 EP disclosed
US-10450408-B2 Method for making polyarylaliphaticetherketone polymers and copolymers thereof KETONEX LIMITED (GB) 2019-10-22 US disclosed
US-10100144-B2 Method for making particulate amine-functionalized polyaryletherketone polymers and copolymers thereof KETONEX LIMITED (GB) 2018-10-16 US disclosed
EP-3145974-B1 METHOD FOR MAKING PARTICULATE AMINE-FUNCTIONALIZED POLYARYLETHERKETONE POLYMERS AND COPOLYMERS THEREOF KETONEX LTD (GB) 2018-04-25 EP disclosed
US-20180105618-A1 N-HALAMINE MELAMINE DERIVATIVES AS NOVEL DECONTAMINATION AND BIOCIDAL AGENTS STATE OF ISRAEL PRIME MINISTER'S OFFICE ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) 2018-04-19 US disclosed
WO-2016038370-A1 METHOD FOR MAKING POLYARYLALIPHATICETHERKETONE POLYMERS AND COPOLYMERS THEREOF KETONEX LIMITED (GB) 2016-03-17 WO disclosed
WO-2015177549-A1 METHOD FOR MAKING PARTICULATE AMINE-FUNCTIONALIZED POLYARYLETHERKETONE POLYMERS AND COPOLYMERS THEREOF KETONEX LIMITED (GB) 2015-11-26 WO disclosed
US-20150337082-A1 PARTICULATE AMINE-FUNCTIONALIZED POLYARYLETHERKETONE POLYMER AND COPOLYMERS THEREOF KETONEX LIMITED (GB) 2015-11-26 US disclosed
WO-2015179587-A1 PARTICULATE AMINE-FUNCTIONALIZED POLYARYLETHERKETONE POLYMER AND COPOLYMERS THEREOF CYTEC INDUSTRIES INC. (US) 2015-11-26 WO disclosed
WO-2015177550-A1 AMINE AND NON-AMINE DERIVATISED POLYARYLETHERKETONE RANDOM AND BLOCK COPOLYMERS KETONEX LIMITED (GB) 2015-11-26 WO disclosed
US-5674398-A THIN FILM OF CROSSLINKED POLYAMIDE OBTAINED BY INTERFACIAL POLYMERIZATION AND MICROPOROUS SUBSTRATE NITTO DENKO CORPORATION (JP) 1997-10-07 US disclosed
EP-0229470-B1 BRANCHED COPOLYETHERKETONES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-01-30 EP disclosed
US-4720537-A Branched copolyetherketones E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-01-19 US disclosed
EP-0229470-A1 Branched copolyetherketones E.I. DU PONT DE NEMOURS AND COMPANY (US) 1987-07-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10450408-B2 Method for making polyarylaliphaticetherketone polymers and copolymers thereof DAO, DCXR, LOX ALDH1A1 815/4885TSHR 1820/4885ALOX15 49/4885
US-20180105618-A1 N-HALAMINE MELAMINE DERIVATIVES AS NOVEL DECONTAMINATION AND BIOCIDAL AGENTS HNMT, CAT, TYR ALDH1A1 946/4885TSHR 2416/4885ALOX15 2793/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.