Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.50 |
| ▸ | METAP2 | P50579 | 7/20 | 0.43 |
| ▸ | METAP1 | P53582 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8913322 | 1.00 | REN (0.50) | RENMETAP2METAP1CYP1A2ALDH1A1 | |
| SCHEMBL8913327 | 1.00 | REN (0.50) | RENMETAP2METAP1CYP1A2ALDH1A1 | |
| SCHEMBL7274162 | 0.95 | REN (0.55) | RENMETAP2METAP1CYP1A2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9848324 | 0.85 | REN (0.47) | RENMETAP2METAP1 | |
| SCHEMBL9417404 | 0.84 | REN (0.49) | RENMETAP2METAP1CYP1A2ALDH1A1 | |
| SCHEMBL9503799 | 0.84 | REN (0.45) | RENMETAP2METAP1 | |
| SCHEMBL9507429 | 0.84 | REN (0.45) | RENMETAP2METAP1 | |
| SCHEMBL9506691 | 0.84 | REN (0.45) | RENMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7317283 | 0.83 | REN (0.48) | RENMETAP2METAP1CYP1A2ALDH1A1 | |
| SCHEMBL7274619 | 0.81 | REN (0.46) | RENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688946-A | DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | HOFFMANN LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |