Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.47 |
| ▸ | WNT1 | P04628 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8912740 | 0.86 | PDE3B (0.46) | PDE3BALDH1A1MAPTTSHRCYP1A2 | |
| SCHEMBL8912135 | 0.81 | CRBN (0.44) | PDE3BGRM5KCNH2SMN1; SMN2KDM5A | |
| SCHEMBL8912023 | 0.77 | CA12 (0.49) | PDE3BALDH1A1L3MBTL1MAPTKCNH2 | |
| SCHEMBL10473805 | 0.77 | PDE3B (0.68) | PDE3BALDH1A1MAPTKCNH2CYP1A2 | |
| SCHEMBL8912191 | 0.77 | NR1H2 (0.49) | PDE3BKCNH2NR1H2SMN1; SMN2PDE3A | |
| SCHEMBL8911986 | 0.76 | MAPT (0.42) | PDE3BALDH1A1L3MBTL1MAPTKCNH2 | |
| SCHEMBL8911889 | 0.76 | CA12 (0.51) | PDE3BALDH1A1L3MBTL1MAPTPDE3A | |
| SCHEMBL8912495 | 0.74 | LMNA (0.46) | PDE3BALDH1A1L3MBTL1MAPTPDE3A | |
| SCHEMBL8303551 | 0.73 | LMNA (0.48) | PDE3BMAPTKCNH2SMN1; SMN2PDE3A | |
| SCHEMBL8108762 | 0.72 | EPHX2 (0.56) | PDE3BALDH1A1MAPTTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605901-A | THERAPY FOR GRAM-NEGATIVE BACTERIA, NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1997-02-25 | — | — | US | claimed |
| US-5543409-A | Indane derivatives for treating endotoxin shock and/or nephritis | TANABE SEIYAKU CO., LTD. (JP) | 1996-08-06 | — | — | US | claimed |
| EP-0661274-A1 | Indane derivatives, processes for preparing the same and synthetic intermediate of the same | TANABE SEIYAKU CO., LTD. (JP) | 1995-07-05 | — | — | EP | claimed |