Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.40 |
| ▸ | PDE4A | P27815 | 6/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8911986 | 0.80 | MAPT (0.42) | SMN1; SMN2PDE3BMEN1KMT2APDE3A | |
| SCHEMBL8912023 | 0.80 | CA12 (0.49) | SMN1; SMN2PDE3BMEN1KMT2APDE3A | |
| SCHEMBL8912135 | 0.80 | CRBN (0.44) | SMN1; SMN2PDE3BKMT2AGPR119PDE3A | |
| SCHEMBL8912495 | 0.79 | LMNA (0.46) | PDE3BMEN1KMT2AEPHX1PDE3A | |
| SCHEMBL8911889 | 0.78 | CA12 (0.51) | PDE3BMEN1KMT2APDE3APDE4A | |
| SCHEMBL8913326 | 0.77 | PDE3B (0.47) | NR1H2SMN1; SMN2PDE3BPDE3APDE4A | |
| SCHEMBL8110725 | 0.77 | SMN1; SMN2 (0.48) | NR1H2SMN1; SMN2GPR119 | |
| SCHEMBL8912187 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2PDE3BMEN1KMT2AGPR119 | |
| SCHEMBL8304547 | 0.74 | PDE3B (0.48) | SMN1; SMN2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10361254 | 0.74 | EPHX2 (0.65) | SMN1; SMN2MEN1KMT2AKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605901-A | THERAPY FOR GRAM-NEGATIVE BACTERIA, NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1997-02-25 | — | — | US | disclosed |
| US-5543409-A | Indane derivatives for treating endotoxin shock and/or nephritis | TANABE SEIYAKU CO., LTD. (JP) | 1996-08-06 | — | — | US | disclosed |
| EP-0661274-A1 | Indane derivatives, processes for preparing the same and synthetic intermediate of the same | TANABE SEIYAKU CO., LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |