Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8913452 | 1.00 | THRB (0.62) | THRBPARP10RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11561163 | 0.87 | THRB (0.66) | THRBPARP10RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11560179 | 0.84 | THRB (0.57) | THRBPARP10RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11560181 | 0.84 | THRB (0.57) | THRBPARP10RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11713147 | 0.83 | THRB (0.60) | THRBPARP10RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11713157 | 0.83 | THRB (0.60) | THRBPARP10RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10923640 | 0.83 | HCAR2 (0.59) | RAB9ANPC1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL11712721 | 0.82 | THRB (0.59) | THRBPARP10RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11712717 | 0.82 | THRB (0.59) | THRBPARP10RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10666475 | 0.81 | ALDH1A1 (0.57) | RAB9ASMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658934-A | Aryl-substituted alkoxycarbonyl-1,4-dihydropyridine-5-carboxylic acid esters | BAYER AKTIENGESELLSCHAFT (DE) | 1997-08-19 | — | — | US | disclosed |
| EP-0657434-A1 | Arylsubstituted -alkoxy-1,4-dihydropyridin-5-carbonic acid esters with cerebral activity | BAYER AG (DE) | 1995-06-14 | — | — | EP | disclosed |
| US-5276150-A | Vasodilators, anticoagulants, calcium channel blockers | FUJIREBIO INC. (JP) | 1994-01-04 | — | — | US | disclosed |
| EP-0400660-A1 | 1,4-dihydropyridine derivatives | FUJIREBIO INC. (JP) | 1990-12-05 | — | — | EP | disclosed |
| US-4798840-A | Coronary-active fluorine-containing 1,4-dihydropyridines | BAYER AKTIENGESELLSCHAFT (DE) | 1989-01-17 | — | — | US | disclosed |
| EP-0225574-A1 | Novel 1,4-dihydropyridines containing fluorine, process for their preparation and their use as medicaments | BAYER AG (DE) | 1987-06-16 | — | — | EP | disclosed |
| EP-0088276-B1 | COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL PREPARATIONS | BAYER AG (DE) | 1986-04-30 | — | — | EP | disclosed |
| EP-0088276-A1 | Compounds, process for their preparation and their use as pharmaceutical preparations | BAYER AG (DE) | 1983-09-14 | — | — | EP | disclosed |
| EP-0012180-A1 | 1,4-Dihydropyridine compounds, their preparation, pharmaceutical compositions containing said compounds and preparation of these compositions | BAYER AG (DE) | 1980-06-25 | — | — | EP | disclosed |
| EP-0002208-A1 | Nitro 1,4-dihydropyridines, medicaments containing them and their manufacture | BAYER AG (DE) | 1979-06-13 | — | — | EP | disclosed |
| EP-0001769-A1 | Sulfur-containing esters of 1,4-dihydropyridine carboxylic acids, their preparation and pharmaceutical use | BAYER AG (DE) | 1979-05-16 | — | — | EP | disclosed |