Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.38 |
| ▸ | CDK1 | P06493 | 4/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8913601 | 0.87 | LMNA (0.46) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL7117145 | 0.86 | LMNA (0.46) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL4149301 | 0.78 | KDM4E (0.57) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL4154426 | 0.75 | KDM4E (0.55) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL7131581 | 0.75 | LMNA (0.44) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL7124395 | 0.74 | LMNA (0.51) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL7127566 | 0.72 | LMNA (0.56) | LMNAPTPN1CHRM1 | |
| SCHEMBL4157847 | 0.71 | KDM4E (0.55) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5007881 | 0.70 | KDM4E (0.47) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL7120371 | 0.70 | LMNA (0.52) | LMNAALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793656-A1 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016046-A2 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-05-30 | — | — | WO | disclosed |