Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.48 |
| ▸ | TOP1 | P11387 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13578556 | 0.91 | LMNA (0.56) | LMNACHRM1PTPN1CNR1CNR2 | |
| SCHEMBL7123296 | 0.85 | P2RX3 (0.55) | LMNAPTPN1CNR1CNR2 | |
| SCHEMBL4149301 | 0.80 | KDM4E (0.57) | LMNAPTPN1 | |
| SCHEMBL8913601 | 0.79 | LMNA (0.46) | LMNACHRM1PTPN1 | |
| SCHEMBL7056189 | 0.79 | LMNA (0.56) | LMNACHRM1 | |
| SCHEMBL10475528 | 0.77 | CAPN1 (0.53) | LMNACHRM1TOP1CAPN1CNR1 | |
| SCHEMBL7131581 | 0.77 | LMNA (0.44) | LMNACHRM1 | |
| SCHEMBL3003393 | 0.76 | LMNA (0.54) | LMNAPTPN1CNR1CNR2 | |
| SCHEMBL5544795 | 0.75 | LMNA (0.73) | LMNACHRM1CNR2 | |
| SCHEMBL2070531 | 0.74 | LMNA (0.71) | LMNACHRM1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793656-B1 | NOVEL BENZYL PYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-03-26 | — | — | EP | disclosed |
| US-5763450-A | BACTERICIDES; TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0793656-A1 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016046-A2 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-05-30 | — | — | WO | disclosed |