Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | GNAI3 | P08754 | 6/20 | 0.44 |
| ▸ | GNAO1 | P09471 | 6/20 | 0.44 |
| ▸ | GNAI1 | P63096 | 6/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8914421 | 1.00 | HRH3 (0.46) | HRH3GNAI3GNAO1GNAI1LTA4H | |
| Iodide SCHEMBL8913931 | 0.96 | HRH3 (0.52) | HRH3GNAI3GNAO1GNAI1LTA4H | |
| SCHEMBL8715077 | 0.90 | LTA4H (0.45) | HRH3GNAI3GNAO1GNAI1LTA4H | |
| SCHEMBL8967237 | 0.89 | HRH3 (0.46) | HRH3GNAI3GNAO1GNAI1LTA4H | |
| SCHEMBL8967292 | 0.89 | HRH3 (0.46) | HRH3GNAI3GNAO1GNAI1LTA4H | |
| Hydrochloric Acid SCHEMBL27376006 | 0.87 | HRH3 (0.45) | HRH3GNAI3GNAO1GNAI1LTA4H | |
| SCHEMBL8966776 | 0.86 | HRH3 (0.43) | HRH3GNAI3GNAO1GNAI1LTA4H | |
| SCHEMBL17432835 | 0.86 | GNAO1 (0.59) | GNAI3GNAO1GNAI1KDM4E | |
| SCHEMBL17432833 | 0.86 | GNAO1 (0.59) | GNAI3GNAO1GNAI1KDM4E | |
| SCHEMBL22271407 | 0.85 | HRH3 (0.55) | HRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614548-A | TREATING TUMORS AND HIV INFECTION, PROTEIN KINASE C INHIBITORS | WAKE FOREST UNIVERSITY (US) | 1997-03-25 | — | — | US | disclosed |