Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 3/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8911929 | 0.84 | PDE4A (0.36) | CYP1A2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8911880 | 0.83 | PDE3B (0.39) | CYP1A2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8913328 | 0.70 | MAPT (0.38) | CYP1A2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8911600 | 0.70 | CA12 (0.52) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL8912025 | 0.69 | PDE4A (0.40) | CYP1A2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8715566 | 0.69 | MAPT (0.44) | CYP1A2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8296106 | 0.69 | PDE3B (0.43) | CYP1A2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8302588 | 0.69 | PDE3B (0.44) | CYP1A2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8913213 | 0.69 | MAPT (0.39) | CYP1A2PDE4APDE4BPDE4CPDE4D | |
| Bromide SCHEMBL8291044 | 0.68 | PDE3B (0.42) | CYP1A2PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605901-A | THERAPY FOR GRAM-NEGATIVE BACTERIA, NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1997-02-25 | — | — | US | disclosed |
| US-5543409-A | Indane derivatives for treating endotoxin shock and/or nephritis | TANABE SEIYAKU CO., LTD. (JP) | 1996-08-06 | — | — | US | disclosed |
| EP-0661274-A1 | Indane derivatives, processes for preparing the same and synthetic intermediate of the same | TANABE SEIYAKU CO., LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |