Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | GFER | P55789 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8911981 | 0.72 | ALDH1A1 (0.47) | ALDH1A1LMNAHTTNPC1TP53 | |
| Hydrochloric Acid SCHEMBL7366582 | 0.72 | HRH1 (0.32) | — | |
| SCHEMBL24832881 | 0.66 | ALDH1A1 (0.48) | MAPTALDH1A1GAAGFERKDM4E | |
| SCHEMBL2692445 | 0.65 | MAPT (0.59) | MAPTALDH1A1GAAGFERKDM4E | |
| SCHEMBL17076656 | 0.64 | CRBN (0.47) | MAPTALDH1A1GAAGFERKDM4E | |
| SCHEMBL22904567 | 0.64 | CRBN (0.47) | MAPTALDH1A1GAAGFERKDM4E | |
| SCHEMBL14041746 | 0.61 | CRBN (0.45) | MAPTALDH1A1GAAGFERKDM4E | |
| SCHEMBL17525066 | 0.61 | CRBN (0.66) | MAPTALDH1A1GAAGFERKDM4E | |
| SCHEMBL6151120 | 0.61 | MAPT (0.77) | MAPTALDH1A1GAAGFERKDM4E | |
| SCHEMBL23347931 | 0.61 | MAPT (0.77) | MAPTALDH1A1GAAGFERKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0431943-A2 | Nitrogen-containing spirocycles | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |