Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | CDC25A | P30304 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8916069 | 0.93 | LMNA (0.50) | KDM4ELMNAAPOBEC3AAPOBEC3GCDC25A | |
| SCHEMBL4904983 | 0.90 | KDM4E (0.50) | KDM4ELMNAAPOBEC3AAPOBEC3GCDC25A | |
| SCHEMBL4901140 | 0.89 | KDM4E (0.53) | KDM4ELMNAAPOBEC3AAPOBEC3GCDC25A | |
| Iodide SCHEMBL8913917 | 0.84 | CDC25A (0.61) | KDM4ELMNAAPOBEC3AAPOBEC3GCDC25A | |
| Iodide SCHEMBL8912476 | 0.84 | GNAI3 (0.50) | KDM4ELMNAAPOBEC3AAPOBEC3GCDC25A | |
| Hydrochloric Acid SCHEMBL10554558 | 0.83 | USP2 (0.50) | KDM4ELMNAAPOBEC3AAPOBEC3GCDC25A | |
| SCHEMBL319566 | 0.82 | KDM4E (0.54) | KDM4ELMNAAPOBEC3AAPOBEC3GCDC25A | |
| SCHEMBL16674108 | 0.82 | KDM4E (0.62) | KDM4ELMNAAPOBEC3AAPOBEC3GCDC25A | |
| SCHEMBL4903008 | 0.80 | KDM4E (0.57) | KDM4ELMNAAPOBEC3AAPOBEC3GCDC25A | |
| Iodide SCHEMBL29788813 | 0.80 | KDM4E (0.68) | KDM4ELMNAAPOBEC3AAPOBEC3GCDC25A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614548-A | TREATING TUMORS AND HIV INFECTION, PROTEIN KINASE C INHIBITORS | WAKE FOREST UNIVERSITY (US) | 1997-03-25 | — | — | US | disclosed |