Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28556525 | 1.00 | TP53 (0.59) | TP53TSHRMAPK1MAOAMAOB | |
| SCHEMBL10456699 | 0.93 | TP53 (0.62) | TP53TSHRMAPK1MAOAMAOB | |
| SCHEMBL10330506 | 0.90 | TP53 (0.69) | TP53TSHRMAPK1MAOAMAOB | |
| SCHEMBL11209054 | 0.90 | TP53 (0.72) | TP53TSHRMAOAMAOBALDH1A1 | |
| SCHEMBL8027361 | 0.88 | TP53 (0.75) | TP53TSHRMAPK1MAOAMAOB | |
| SCHEMBL10330516 | 0.87 | LMNA (0.63) | TP53TSHRMAPK1ALDH1A1LMNA | |
| SCHEMBL10330501 | 0.86 | TP53 (0.79) | TP53TSHRMAPK1LMNAMAPT | |
| SCHEMBL10330500 | 0.84 | KMT2A (0.58) | TP53TSHRMAPK1ALDH1A1LMNA | |
| SCHEMBL14020066 | 0.84 | TP53 (0.59) | TP53TSHRMAOAMAOBALDH1A1 | |
| SCHEMBL8659026 | 0.84 | TP53 (0.64) | TP53MAOAMAOBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654451-A | GUANIDINE AND/OR NITROGUANIDINE-CONTAINING BIS/DI- OR TRIPEPTIDES/ COUPLED BY A DIAMINE; VIRICIDES; ANTIPROTOZOA AGENTS; FUNGICIDES; PARASITICIDES; DRUG DELIVERY; MEMBRANE TRANSPORTATION | MAGAININ PHARMACEUTICALS INC. (US) | 1997-08-05 | — | — | US | disclosed |