Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.45 |
| ▸ | PDE4A | P27815 | 6/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8912378 | 0.88 | MAPT (0.40) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL8912302 | 0.87 | MAPT (0.42) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL8911969 | 0.86 | PDE3B (0.40) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL8303551 | 0.76 | LMNA (0.48) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL8911889 | 0.76 | CA12 (0.51) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL8912023 | 0.75 | CA12 (0.49) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL8300078 | 0.75 | MAPT (0.46) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL8911986 | 0.74 | MAPT (0.42) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL8911629 | 0.74 | MAPT (0.42) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL8302599 | 0.73 | PDE3B (0.46) | PDE3BPDE3APDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605901-A | THERAPY FOR GRAM-NEGATIVE BACTERIA, NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1997-02-25 | — | — | US | disclosed |
| US-5543409-A | Indane derivatives for treating endotoxin shock and/or nephritis | TANABE SEIYAKU CO., LTD. (JP) | 1996-08-06 | — | — | US | disclosed |
| EP-0661274-A1 | Indane derivatives, processes for preparing the same and synthetic intermediate of the same | TANABE SEIYAKU CO., LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |